Browse our latest Medicine articles

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    1. Computational and Systems Biology
    2. Medicine

    Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

    Muhammad Arif, Martina Klevstig ... Jan Boren
    Elucidating widespread and tissue-specific biological process alterations after myocardial infaction in metabolically active tissues using systems biology approaches.
    1. Computational and Systems Biology
    2. Medicine

    Heart Attack: Working together

    Regan Odongo, Tunahan Çakır
    Heart attacks have a ripple effect on how other organs exchange biomolecules that help the heart respond to injury.
    Version of Record
    Insight
    1. Epidemiology and Global Health
    2. Medicine

    Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

    Heli Julkunen, Anna Cichońska ... Nightingale Health UK Biobank Initiative
    Metabolic biomarkers measured from single blood test can identify apparently healthy people at high susceptibility for developing severe pneumonia, and may also be useful for preventive COVID-19 screening.
    1. Epidemiology and Global Health
    2. Medicine

    An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

    Torsten Dahlén, Mark Clements ... Gustaf Edgren
    The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.
    1. Medicine

    Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

    Fernanda I Staquicini, Amin Hajitou ... Renata Pasqualini
    A peptide motif targeting tumor-infiltrating macrophage in triple-negative breast cancer delays tumor growth and favors an antitumor immune response.
    1. Medicine

    Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

    Christian A Di Buduo, Pierre-Alexandre Laurent ... Alessandra Balduini
    A 3D bone marrow niche that reproduces megakaryocyte differentiation and ex vivo platelet production from hematopoietic progenitors and iPSCs of thrombocytopenic patients predicts individual response to Eltrombopag accurately.
    1. Epidemiology and Global Health
    2. Medicine

    Mapping the endemicity and seasonality of clinical malaria for intervention targeting in Haiti using routine case data

    Ewan Cameron, Alyssa J Young ... Katherine E Battle
    A demonstration of the power of routine case data and statistical modelling to guide the allocation of anti-malarial interventions in a resource-constrained setting.
    1. Medicine
    2. Neuroscience

    Recovery of consciousness and cognition after general anesthesia in humans

    George A Mashour, Ben JA Palanca ... Max B Kelz
    Cognitive reconstitution after pharmacologic unconsciousness is an extended process, executive function is more robust than expected, and the healthy human brain is resilient to the effects of deep general anesthesia.
    1. Genetics and Genomics
    2. Medicine

    A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

    Qingyuan Zhao, Jingshu Wang ... Daniel J Rader
    High-density lipoprotein (HDL) subfraction traits appear to have heterogeneous effects on coronary artery disease, giving support to the HDL function hypothesis.
    1. Medicine

    Development and validation of a nomogram to better predict hypertension based on a 10-year retrospective cohort study in China

    Xinna Deng, Huiqing Hou ... Haijiang Wu
    A developed and validated nomogram better predicts the risk of hypertension based on a 10-year retrospective cohort study in China.