Browse our latest Medicine articles

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    1. Medicine

    Equity, Diversity and Inclusion: Introducing the MAVEN Leadership Training Initiative to diversify the scientific workforce

    Y Claire Wang, Elizabeth Brondolo ... The MAVEN Leadership Team
    The MAVEN Initiative has been designed to encourage mid-career women scientists, particularly women of color, to move into leadership positions in science.
    1. Computational and Systems Biology
    2. Medicine

    Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

    Savannah F Bifulco, Griffin D Scott ... Patrick M Boyle
    In models reconstructed from MRI scans of patients with embolic stroke of undetermined source, computational simulations reveal that fibrosis has the intrinsic capacity to sustain arrhythmia drivers when subjected to triggered activity known to exist in patients with atrial fibrillation.
    1. Immunology and Inflammation
    2. Medicine

    Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics

    Juana Serrano-Lopez, Shailaja Hegde ... Jose A Cancelas
    Endotoxemia recruits fast-acting anti-inflammatory innate myeloid progenitors from bone marrow into regional lymphatics through release of pre-formed Ccl19 secondary to NF-κB-independent, Traf6/IκB kinase-dependent signaling.
    1. Epidemiology and Global Health
    2. Medicine

    Effects of an urban sanitation intervention on childhood enteric infection and diarrhea in Maputo, Mozambique: A controlled before-and-after trial

    Jackie Knee, Trent Sumner ... Joe Brown
    Onsite sanitation maybe insufficient to interrupt transmission of enteric infections in high-burden urban settings, though risk of some infections may be reduced among children protected from birth.
    1. Medicine

    Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

    Salwa Naushin, Viren Sardana ... Shantanu Sengupta
    Widespread asymptomatic SARS-CoV2 infection affected nearly 100 million Indians by September 2020 with a subsequent decline in new cases, which may be attributable to increased population immunity, albeit seeing reduced neutralization activity at 6 months this respite may be temporary.
    1. Medicine

    Coronary plaque composition influences biomechanical stress and predicts plaque rupture in a morpho-mechanic OCT analysis

    Andrea Milzi, Enrico Domenico Lemma ... Mathias Burgmaier
    Assessing plaque biomechanics by optical coherence tomography highlights the importance of the disrupting effects of plaque stress, bringing stress concentrations as the prime movers of plaque rupture back into clinical practice.
    1. Medicine

    Asprosin-neutralizing antibodies as a treatment for metabolic syndrome

    Ila Mishra, Clemens Duerrschmid ... Atul R Chopra
    Anti-asprosin monoclonal antibodies, a promising pharmacotherapy for the treatment of metabolic syndrome-associated hyperglycemia, obesity, and dyslipidemia.
    1. Cell Biology
    2. Medicine

    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

    Takeshi Ninchoji, Dominic T Love ... Lena Claesson-Welsh
    Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.
    1. Medicine
    2. Neuroscience

    Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials

    Maria M Cobo, Caroline Hartley ... Rebeccah Slater
    Measuring individual differences in noxious-evoked baseline sensitivity in neonates can substantially reduce sample sizes required in neonatal analgesic trials.
    1. Medicine

    Sensitivity of ID NOW and RT–PCR for detection of SARS-CoV-2 in an ambulatory population

    Yuan-Po Tu, Jameel Iqbal, Timothy O'Leary
    Although the ID NOW platform is less sensitive than RT–PCR for identification of SARS-CoV-2 infection, it provides high positive and negative predictive values in low-prevalence populations.