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    1. Medicine

    Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis

    Sindre Lee-Ødegård, Marit Hjorth ... Kåre Inge Birkeland
    Long-term physical exercise had a substantial effect on the plasma proteome, identifying novel exerkines and suggesting CD300LG as a potential link to insulin sensitivity.
    1. Medicine

    Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

    Yohei Nitta, Jiro Osaka ... Atsushi Sugie
    Dominant optic atrophy (DOA) and DOA plus mutations' effects on optic nerve degeneration distinguished in a novel Drosophila model.
    1. Medicine
    2. Neuroscience

    The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: a safety study

    Gansheng Tan, Anna L Huguenard ... Eric C Leuthardt
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Medicine

    AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

    Zongwang Zhang, Lixia Zheng ... Jing-Wei Xiong
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Immunology and Inflammation

    JAK inhibition decreases the autoimmune burden in Down syndrome

    Angela L Rachubinski, Elizabeth Wallace ... Joaquin M Espinosa
    Not revised
    Reviewed Preprint v1
    1. Medicine

    A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria

    Tumininu S Faniyan, Xinyi Zhang ... Kavaljit H Chhabra
    Targeting the interaction between the kidneys and brain may increase the efficiency of SGLT2 inhibitors to better manage type 2 diabetes.
    1. Developmental Biology
    2. Medicine

    SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction

    Stephen E Flaherty III, Olivier Bezy ... Zhidan Wu
    Investigation of mouse models from forward mutagenetic screen reveals that the gene Spag7 is essential for embryonic development and energy homeostasis later in life.
    1. Medicine

    Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

    Christin Krause, Jan H Britsemmer ... Henriette Kirchner
    The liver microRNA transcriptome of humans with type 2 diabetes and obesity is analyzed for the first time and compared with diet-induced obesity in mice.
    1. Immunology and Inflammation
    2. Medicine

    Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

    Joanna C Porter, Jamie Inshaw ... Venizelos Papayannopoulos
    Nebulized dornase alfa endonuclease reduces inflammation, coagulopathy, and the length of hospitalization in individuals with severe COVID-19 pneumonia.
    1. Medicine

    Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study

    Ruijie Zeng, Yuying Ma ... Hao Chen
    Proton pump inhibitors are associated with an increased susceptibility to respiratory infections.
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