About
Editors and people

Editors for Biochemistry and Chemical Biology

We aim to review studies that provide new insights into the structure, function, and regulation of biological molecules including proteins, nucleic acids, lipids, carbohydrates, and natural products. In addition, we are interested in studies that illuminate complex biological processes using chemical tools and approaches. Read the latest research in this subject area.

Type

Senior editors

Amy H Andreotti

Iowa State University, United States

Amy Andreotti is the Roy J Carver Chair in Biochemistry and a University Professor at Iowa State University. She joined the faculty of the Roy J Carver Department of Biochemistry, Biophysics and Molecular Biology in 1997 after earning her PhD in Chemistry at Princeton University and completing a postdoctoral training period in the Chemistry Department at Harvard University where she was a Science Scholar at the Bunting Institute of Radcliffe College. Her work explores the mechanisms of kinase regulation during cell signaling with an emphasis on the immune specific TEC family of non-receptor tyrosine kinases. A particular focus of the lab is Bruton’s tyrosine kinase (BTK) and its interactions with small molecule therapeutics. Her lab uses a variety of biochemical, enzymatic and structural biology methods including solution NMR spectroscopy.

Expertise
Structural Biology and Molecular Biophysics
Biochemistry and Chemical Biology

Research focus
NMR spectroscopy
kinase regulation
cell signalling
Tec family kinases

Experimental organism
human

Competing interests statement
Amy Andreotti's research is currently funded by the National Institutes of Health. She also serves on the National Advisory Committee for the Biomedical Scholars program of the Pew Charitable Trusts.
Qiang Cui

Boston University, United States

Qiang Cui is a professor of Chemistry at Boston University and also affiliated with the Departments of Physics and Biomedical Engineering. He received a B.S. in Chemical Physics from the University of Science and Technology of China in 1993, and a Ph.D. in Theoretical Chemistry in 1997 from Emory University under the tutelage of Professor Keiji Morokuma. He conducted postodctoral research with Professor Martin Karplus at Harvard University and, in 2001, moved to the University of Wisconsin, Madison, as a faculty member in the Chemistry department. After spending almost 17 wonderful years in Madison, he moved back to Boston in 2018. His current research interests include quantum chemistry and statistical mechanics and their applications to various chemical, biological, and materials problems.

Expertise: Computational biophysics, especially molecular dynamics, hybrid quantum mechanical/molecular mechanics simulations, free energy simulations applied to enzymes, biomolecular machines and lipid membranes.

Expertise
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics

Research focus
molecular dynamics
hybrid quantum
classical simulations
enzyme catalysis
allostery
protein dynamics
membrane remodeling

Competing interests statement
Qiang Cui currently serves as an associate editor for the Journal of Chemical Theory and Computation (American Chemical Society).
Volker Dötsch

Goethe University, Germany

Volker Dötsch is Professor of Biophysical Chemistry at Goethe University and a member of the Magnetic Resonance Center Frankfurt. He studied chemistry at the University of Göttingen and obtained a PhD from the ETH in Zürich. As a postdoctoral fellow he used NMR to determine the structure of protein-DNA complexes at the Harvard Medical School. In 1998 he moved as assistant professor to the University of California San Francisco (UCSF). In 2003 he was appointed professor at the Institute of Biophysical Chemistry of Goethe University in Frankfurt. His research interests focus on the structural and functional characterization of members of the p53 protein family, in particular p63 and its involvement in genetic quality control in germ cells. In addition, his laboratory uses a combination of NMR spectroscopy and cell-free protein expression to investigate the structure and function of membrane proteins and studies molecular interactions regulating autophagy. His lab uses a wide variety of biophysical methods including NMR spectroscopy and combines these studies with investigations in cell culture experiments and mouse models. Volker Dötsch is an elected EMBO member.

Expertise
Structural Biology and Molecular Biophysics
Biochemistry and Chemical Biology

Research focus
p53 protein family
cell-free expression and membrane protein structure and function
autophagy

Competing interests statement
Volker Dötsch has received funding from the Deutsche Forschungsgemeinschaft, the National Institutes of Health and the Deutsche Krebshilfe. He is on the Scientific Advisory Board of the Frankfurt Institute of Advanced Studies and a member of the editorial boards of Journal of Biological Chemistry and Cell Death & Disease.
David James

University of Sydney, Australia

Professor James currently holds the Leonard P Ullmann Chair in Molecular Systems Biology and he is the Domain Leader for Biology at the Charles Perkins Centre, University of Sydney. Professor James has made major contributions to our understanding of insulin action. In the late 1980s he published a series of journal articles in Nature describing the identification and characterization of the insulin responsive glucose transporter GLUT4. Professor James then focused his efforts on unveiling the cellular and molecular control of insulin-stimulated glucose transport. He has also made contributions in the area of SNARE proteins, signal transduction and more recently in systems biology.

Expertise
Biochemistry and Chemical Biology
Cell Biology

Research focus
diabetes
signal transduction
systems biology

Experimental organism
mouse
human
rat

Competing interests statement
David James has been funded by bodies like National Health and Medical Research Council (NHMRC), Wellcome Trust, Australian Research Council (ARC), NIH, Pfizer, Eli Lilly and Novo, had continuous NHMRC research fellowships since 1998 and is now Senior Principal Research Fellow.

James has served on editorial boards of journals such as The Journal of Biological Chemistry and The American Journal of Physiology for more than 10 years and is currently on five boards with major roles at Cell Metabolism (only Australian) and The Journal of Clinical Investigation. James reviews ~30 manuscripts per year for journals like Nature, Nature Cell Biology, Nature Medicine, Science, PNAS, The Journal Clinical Invest, Molecular Endocrinology, Endocrinology, Molecular Biology of the Cell, Journal of Cell Biology, Traffic, FASEB J, Genes & Development and grants for Diabetes Australia, National Heart, Wellcome Trust, ARC, NHMRC and International Foundations.
Pankaj Kapahi

Buck Institute for Research on Aging, United States

Dr Kapahi received his PhD from the University of Manchester, where he worked with Tom Kirkwood. He did his postdoctoral work with Seymour Benzer at Caltech and Michael Karin at University of California, San Diego. He joined the Buck Institute as an assistant professor in 2004.

Dr Kapahi has published more than 80 scientific papers and holds three current patents. He has been recognized for his scientific excellence with many awards, including the Eureka Award from the National Institute on Aging, a New Scholar Award from the Ellison Medical Foundation, a Glenn Award for Research in Biological Mechanisms of Aging, the Nathan Shock Young Investigator Award, and the Breakthrough in Gerontology and Julie Martin Mid-career awards from AFAR. Dr. Kapahi also initiated the first master’s degree course in gerontology at the Buck Institute. His lab studies the genetic mechanisms by which nutrients modulate aging and age-related disease.

Expertise
Biochemistry and Chemical Biology
Developmental Biology

Research focus
aging
age-related diseases
nutrient signaling
metabolism
inflammation

Experimental organism
C. elegans
D. melanogaster
E. coli
mouse

Competing interests statement
Dr Kapahi currently hold grants from the NIH, Hillblom Foundation, Hevolution Foundation. He is also founder of a start up in the aging field, Juvify.
Benoît Kornmann

University of Oxford, United Kingdom

Benoit Kornmann is Associate Professor at the Department of Biochemistry, University of Oxford, and fellow of St Hugh’s College. Benoit Kornmann studies membrane contact sites, how intracellular organization impinges on organelle function and how lipid molecules are distributed among the many membranes of a eukaryotic cell. Benoit Kornmann is an expert in yeast genetics, membrane biology, organelle dynamics and signalling. He holds a PhD of the University of Geneva, and previously held the positions of Assistant Professor at the ETH Zurich, Professor of the Swiss National Science Foundation, and fellow of the Swiss National Science Foundation.

Expertise
Biochemistry and Chemical Biology
Cell Biology
Genetics and Genomics

Research focus
membrane contact sites
mitochondria
membrane dynamics
membrane trafficking
phospholipids

Experimental organism
S. cerevisiae

Competing interests statement
Benoit Kornmann is funded by the Wellcome trust and Syngenta Crop Protection. He is a board member of Review Commons and Contact, a faculty member of Faculty Opinions, and an advisory board member of F1000 Research.
Merritt Maduke

Stanford University School of Medicine, United States

Merritt Maduke is an Associate Professor of Molecular & Cellular Physiology and co-director of the Neurosciences Interdisciplinary Graduate Program at Stanford University School of Medicine. She received her PhD in Chemistry from the University of California, San Diego and did postdoctoral training at Brandeis University with Professor Chris Miller. Her research at Stanford is centered on the biophysics of ion channels and transporters, with the overarching goal of understanding molecular mechanisms within the context of physiological functions. She also applies her mechanistic approach in the field of ultrasound neuromodulation. She was awarded the Society of General Physiologist’s Cranefield Award for her research on ion channels (2008) and served as the Society’s President from 2018-2019.

Expertise
Structural Biology and Molecular Biophysics
Neuroscience
Biochemistry and Chemical Biology

Research focus
ion channel and transporter molecular mechanisms
ion channel and transporter physiology
ion channel and transporter pharmacology
ultrasound neuromodulation

Experimental organism
E. coli
mouse
rat

Competing interests statement
Merritt Maduke is employed by Stanford University and receives research funding from the National Institutes of Health and Stanford Innovative Medicine Accelerator. She has served on the BPNS and BBM study sections at the NIH and as ad hoc member of additional panels. She serves on the editorial boards of the Biophysical Journal and The Journal of General Physiology and is a founding curator for Biophysics Colab.
David Ron

Cambridge University, United Kingdom

David Ron is a Professor at Cambridge University. He directs a lab at the Cambridge Institute for Medical Research (CIMR) studying protein-folding homeostasis in the endoplasmic reticulum (ER). The lab uses biochemical, biophysical and cell-based tools to research both the molecular mechanisms that recognize the burden of unfolded proteins and thus initiate signalling in the ER unfolded protein response (UPR) and the downstream effector pathways by which cells adapt to unfolded protein stress in their ER. These effector mechanisms engage post-translational regulation of ER chaperone function, regulated translation of mRNA and transcriptional control of gene expression and thus interface with other cellular stress pathways.

To eLife, David Ron brings scientific expertise in the study of the unfolded protein response, chaperone function and stress-induced regulation of mRNA translation and editorial experience from having served as an eLife Reviewing Editor since 2012.

Expertise
Biochemistry and Chemical Biology
Cell Biology

Research focus
chaperones
unfolded protein response
oxidative protein folding
protein synthesis

Experimental organism
C. elegans
E. coli
human
mouse
S. cerevisiae

Competing interests statement
David Ron holds a Wellcome Trust Principal Research Fellowship and is on the editorial advisory boards of J. Cell Science, PLOS Biology and EMBO J.
Dominique Soldati-Favre

University of Geneva, Switzerland

Dr Dominique Soldati-Favre studied biochemistry and earned her PhD degree in molecular biology from the University of Zürich (Switzerland). She is full Professor at the department of Microbiology and Molecular Medicine at the Faculty of Medicine of the University of Geneva. Her laboratory is studying obligate intracellular parasitism using Toxoplasma gondii. The main line of research focuses on the cell biology underlying parasite active invasion into mammalian cells. Her group is also aiming at defining the metabolic needs and capabilities of the parasites as well as how they subvert host cellular functions notably to access nutrients.

Expertise
Microbiology and Infectious Disease
Biochemistry and Chemical Biology
Cell Biology
Genetics and Genomics

Research focus
parasitology
organelle biogenesis
protein trafficking
metabolism
host pathogen interaction
signalling

Experimental organism
T. gondii
apicomplexans
kinetoplastids

Competing interests statement
Dominique Soldati-Favre’s research is currently funded by the Swiss National Science Foundation. She serves as Section Editor at PLOS Pathogens, and Editor at mBio.
Kenton J Swartz

National Institute of Neurological Disorders and Stroke, NIH, United States

Kenton Swartz has been a Senior Investigator in the National Institute of Neurological Disorders and Stroke within the National Institutes of Health in Bethesda, Maryland since 2003. He obtained a BS in Chemistry and Biology from Eastern Mennonite College in 1986 and a PhD in Neurobiology from Harvard Medical School in 1993, where he worked with Bruce Bean studying the regulation of voltage-gated calcium channels by G-proteins and protein kinases. He obtained postdoctoral training with Roderick MacKinnon at Harvard Medical School, where he began isolating and studying toxins that interact with voltage-activated potassium channels. His laboratory uses biochemical, molecular biological, biophysical and structural techniques to understand how ion channel proteins sense critical biological stimuli, including membrane voltage, temperature, and both chemical and mechanical signals. He received an NIH Directors Award for Scientific Achievement in 2008, an NIH Office of the Director Honor Award on behalf of the Diversity Task Force in 2011 and the Kenneth S. Cole Award from the Biophysical Society in 2017. He has also served as the president of the Society of General Physiologists.

Expertise
Structural Biology and Molecular Biophysics
Neuroscience
Biochemistry and Chemical Biology

Research focus
ion channel structure
ion channel mechanisms
ion channel physiology
ion channel pharmacology

Experimental organism
mouse

Competing interests statement
Kenton Swartz is employed by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, National Institutes of Health. In addition to serving as a Senior Editor at eLife, he has served as a Reviewing Editor for eLife and as an Associate Editor at the Journal of General Physiology. He also teaches yoga at LifeTime Athletic.

Reviewing editors

Fernán Agüero

Universidad Nacional de San Martín, Argentina

Expertise
Biochemistry and Chemical Biology
Chromosomes and Gene Expression
Computational and Systems Biology
Evolutionary Biology
Genetics and Genomics
Immunology and Inflammation
Microbiology and Infectious Disease

Research focus
genomics
drug discovery
diagnostics
infectious diseases
microbial eukaryotes
bioinformatics
Sameh Ali

Children's Cancer Hospital Egypt, Egypt

Expertise
Biochemistry and Chemical Biology
Cancer Biology
Cell Biology
Immunology and Inflammation
Neuroscience
Structural Biology and Molecular Biophysics

Research focus
metabolism
mitochondria
redox biology
reactive oxygen species
membrane biophysics
inflammation
aging
oncology
Warren Andayi

Murang'a University of Technology, Kenya

Expertise
Biochemistry and Chemical Biology
Microbiology and Infectious Disease

Research focus
chemical biology
drug discovery
drug development
phytochemistry
infectious diseases
pharmacology
organic synthesis
analytical chemistry
STEM education
Aseem Z Ansari

St. Jude Children's Research Hospital, United States

Expertise
Chromosomes and Gene Expression
Biochemistry and Chemical Biology
Genetics and Genomics

Research focus
gene expression
chemical biology
synthetic biology
transcription factors
molecular recognition
synthetic gene regulators
transcription therapy
RNA polymerase II regulation
transcriptional kinases
DNA binding specificity
Caetano Antunes

University of Kansas, United States

Expertise
Biochemistry and Chemical Biology
Genetics and Genomics
Microbiology and Infectious Disease

Research focus
microbiome
host-microbe interactions
metabolomics
gene regulation
microbial signaling
Daniel Arango

Northwestern University, United States

Expertise
Biochemistry and Chemical Biology
Genetics and Genomics

Research focus
RNA modifications
mRNA processing
mRNA translation
mRNA stability
Hossein Ardehali

Northwestern University, United States

Expertise
Medicine
Biochemistry and Chemical Biology

Research focus
mitochondria
iron
glucose metabolism
mRNA-binding proteins
hexokinases
metabolism
cardiac biology
Anton M Bennett

Yale University, United States

Expertise
Cell Biology
Biochemistry and Chemical Biology
Cancer Biology

Research focus
cell signalling
metabolism
protein tyrosine phosphorylation
protein tyrosine kinases
protein tyrosine phosphatases
Amie K Boal

Pennsylvania State University, United States

Expertise
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics

Research focus
bioinorganic chemistry
enzymes
microbial chemistry
x-ray crystallography
Michael R Botchan

University of California, Berkeley, United States

Expertise
Biochemistry and Chemical Biology
Chromosomes and Gene Expression

Research focus
DNA replication
DNA repair

Experimental organism
D. melanogaster
Francesca Bottanelli

Freie Universitat Berlin, Germany

Expertise
Cell Biology
Biochemistry and Chemical Biology

Research focus
membrane trafficking
organelles
CRISPR
gene editing
super resolution microscopy
Jeffrey J Brault

Indiana University, United States

Expertise
Cell Biology
Biochemistry and Chemical Biology

Research focus
skeletal muscle
bioenergetics
mitochondria
atrophy
ATP

Experimental organism
mouse
Paula Casati

Center of Photosynthetic And Biochemical Studies (CEFOBI), Argentina

Expertise
Biochemistry and Chemical Biology
Chromosomes and Gene Expression
Plant Biology

Research focus
genome stability
abiotic stress in plants
chromatin remodelling
cell cycle regulation
flavonoid metabolism
Agnieszka Chacinska

University of Warsaw, Poland

Expertise
Biochemistry and Chemical Biology
Cell Biology

Research focus
biogenesis
organelles
mitochondria
protein transport
proteasome
protein degradation
protein synthesis

Experimental organism
S. cerevisiae
mammalian cells
nematode
Jose Renato Rosa Cussiol

Federal University of São Paulo, Brazil

Expertise
Biochemistry and Chemical Biology
Cell Biology
Cancer Biology
Genetics and Genomics
Chromosomes and Gene Expression

Research focus
DNA damage response
yeast genetics
DNA damage signaling
genomic instability
inositol metabolism
inositol polyphosphate pathway
Laura Dassama

Stanford University, United States

Expertise
Biochemistry and Chemical Biology
Microbiology and Infectious Disease

Research focus
bacterial multidrug resistance
chemoenzymatic syntheses
beta-hemoglobinopathies
Irwin Davidson

Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, France

Expertise
Biochemistry and Chemical Biology
Cancer Biology
Chromosomes and Gene Expression

Research focus
transcription
chromatin
genomics
cancer

Experimental organism
human
mouse
Martin S Denzel

Altos Labs, Cambridge Institute of Science, United Kingdom

Expertise
Biochemistry and Chemical Biology
Genetics and Genomics

Research focus
aging
metabolism
protein homeostasis
cell culture

Experimental organism
C. elegans
mouse
Stephen C Ekker

Mayo Clinic, United States

Expertise
Developmental Biology
Biochemistry and Chemical Biology

Research focus
gene editing
morpholinos
transposons
mitochondria
health engineering

Experimental organism
zebrafish
Aaron Frank

Arrakis Therapeutics, United States

Expertise
Structural Biology and Molecular Biophysics
Biochemistry and Chemical Biology

Research focus
molecular modeling
biophysics
structural biology
computation
RNA biochemistry
RNA structural biology
Adam Frost

University of California, San Francisco, United States

Expertise
Structural Biology and Molecular Biophysics
Biochemistry and Chemical Biology
Cell Biology

Research focus
cryo-EM
electron cryo-microscopy
membranes
membrane remodeling
proteostasis
stress responses
translation
mitochondria
nuclear envelope
intracellular trafficking
Mari Gantner

The Lowy Medical Research Institute, United States

Expertise
Biochemistry and Chemical Biology
Cell Biology
Medicine

Research focus
retinal disease
retinal metabolism
patient metabolomics
amino acid metabolism
sphingolipid biology
Retinal pigment epithelium (RPE) biology
Karine A Gibbs

Harvard University, United States

Expertise
Microbiology and Infectious Disease
Biochemistry and Chemical Biology

Research focus
Proteus mirabilis
sociomicrobiology
bacterial genetics
kin discrimination
self/non-self recognition
Gustavo H Goldman

Universidade de Sao Paulo, Brazil

Expertise
Biochemistry and Chemical Biology
Cell Biology
Chromosomes and Gene Expression
Genetics and Genomics
Microbiology and Infectious Disease

Research focus
filamentous fungi
Aspergillus
secondary metabolites
gene expression
molecular biology
infectious diseases
drug tolerance
Martin Graña

Institut Pasteur de Montevideo, Uruguay

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Evolutionary Biology
Physics of Living Systems
Structural Biology and Molecular Biophysics

Research focus
protein 3D structure
structural bioinformatics
structure/function relationships
evolution
Iqbal Hamza

University of Maryland, United States

Expertise
Biochemistry and Chemical Biology
Cell Biology
Genetics and Genomics

Research focus
metals
anemia
iron
heme

Experimental organism
mouse
C. elegans
parasites
Johannes Herrmann

University of Kaiserslautern, Germany

Expertise
Cell Biology
Biochemistry and Chemical Biology

Research focus
mitochondria
organelles
protein transport
protein folding
proteostasis
redox biology
respiration

Experimental organism
S. cerevisiae
Heedeok Hong

Michigan State University, United States

Expertise
Structural Biology and Molecular Biophysics
Biochemistry and Chemical Biology

Research focus
membrane proteins
membrane protein folding
membrane protein stability
rhomboid proteases
ATP-dependent proteolysis
AAA+
GlpG
FtsH
John Janetzko

University of Colorado Anschutz Medical Campus, United States

Expertise
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics

Research focus
GPCRs
cryo-EM
X-ray crystallography
Single-molecule FRET
mass spectrometry
phosphoinositide signaling
post translational modifications
glycosyltransferases
Omowumi Kayode

Mountain Top University, Nigeria

Expertise
Biochemistry and Chemical Biology
Cancer Biology
Cell Biology
Immunology and Inflammation
Medicine

Research focus
biochemistry
nutrition
cancer
male sexual function
reproductive tissues
David M Kramer

Michigan State University, United States

Expertise
Biochemistry and Chemical Biology
Plant Biology
Physics of Living Systems
Computational and Systems Biology

Research focus
photosynthesis
bioenergetics
electron and proton transfer
computation
phenotyping
phenomics
Anand Krishnan

University of the Free State, South Africa

Expertise
Biochemistry and Chemical Biology
Cancer Biology
Immunology and Inflammation
Stem Cells and Regenerative Medicine

Research focus
molecular medicine
nanotoxicology
chemical pathology
extracellular vesicles
Karsten Kruse

University of Geneva, Switzerland

Expertise
Biochemistry and Chemical Biology
Physics of Living Systems

Research focus
cell migration
cell signalling
theoretical biology
molecular evolution
Tapas K Kundu

Jawaharlal Nehru Centre for Advanced Scientific Research, India

Expertise
Cancer Biology
Chromosomes and Gene Expression
Biochemistry and Chemical Biology

Research focus
epigenetics
chromatin organization
nonhistone chromatin proteins
epigenetic regulation of diseases
eukaryotic transcription regulation
small molecule modulators of epigenetic enzymes

Experimental organism
human
mouse
Ashish Lal

National Institutes of Health, United States

Expertise
Cancer Biology
Biochemistry and Chemical Biology
Chromosomes and Gene Expression
Genetics and Genomics

Research focus
RNA biology
lncRNAs
microRNAs
gene regulation
cancer biology
p53

Experimental organism
human
Dudley W Lamming

University of Wisconsin-Madison, United States

Expertise
Medicine
Biochemistry and Chemical Biology

Research focus
aging
physiology
dietary restriction
amino acids
diabetes
obesity
metabolism
protein

Experimental organism
mouse
Joanne Lemieux

University of Alberta, United States

Expertise
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics

Research focus
protease
intramembrane protease
crystallography
membrane proteins
structural biology
Chang Liu

Johns Hopkins University, United States

Expertise
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
Microbiology and Infectious Disease

Research focus
coronavirus
cryo-EM
viral replication
transcriptional regulation
virus-host interactions
RNA structure and processing
ribonucleoprotein complex
Andrei Lupas

Max Planck Institute for Developmental Biology, Germany

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Structural Biology and Molecular Biophysics
Evolutionary Biology

Research focus
bacterial surface proteins
bioinformatics
coiled coils
protein design
protein evolution
protein structure
transmembrane signal tranduction
Koyeli Mapa

Shiv Nadar University, India

Expertise
Biochemistry and Chemical Biology

Research focus
proteostasis
chaperones
stress response
unfolded protein response
heat shock proteins
mitochondria
protein folding

Experimental organism
yeast
human cells
E. coli
Fabrizio Marinelli

Medical College of Wisconsin, United States

Expertise
Structural Biology and Molecular Biophysics
Biochemistry and Chemical Biology

Research focus
computational biophysics
molecular dynamics
membrane proteins
membrane transporters
ion channels
membrane remodeling
integrative structural biology
computational methods development
Malcolm J McConville

University of Melbourne, Australia

Expertise
Microbiology and Infectious Disease
Biochemistry and Chemical Biology

Research focus
protozoan parasites
metabolomics
metabolism
Leishmaniasis
trypanosomatids
glycobiology

Experimental organism
T. gondii
Marcelo A Mori

State University of Campinas, Brazil

Expertise
Biochemistry and Chemical Biology
Cell Biology
Chromosomes and Gene Expression
Genetics and Genomics
Immunology and Inflammation

Research focus
aging
metabolism
obesity
adipose tissue
microRNAs
endocrinology
integrative physiology
Hitoshi Nakatogawa

Tokyo Institute of Technology, Japan

Expertise
Cell Biology
Biochemistry and Chemical Biology

Research focus
molecular mechanisms of autophagy
protein/organelle degradation
membrane dynamics

Experimental organism
S. cerevisiae
P Darrell Neufer

East Carolina University, United States

Expertise
Biochemistry and Chemical Biology
Cell Biology
Medicine

Research focus
metabolic disease
mitochondrial bioenergetics
cellular bioenergetics
mitochondrial biogenesis and exercise

Experimental organism
human
flies
rat
mouse
Hannes Neuweiler

University of Würzburg, Germany

Expertise
Structural Biology and Molecular Biophysics
Biochemistry and Chemical Biology

Research focus
protein folding
protein dynamics
protein engineering
fluorescence spectroscopy
fluorescence probes
kinetics
single-molecule fluorescence spectroscopy
Kassandra Ori-McKenney

University of California , United States

Expertise
Biochemistry and Chemical Biology
Cell Biology
Neuroscience

Research focus
microtubules
microtubule-associated proteins
microtubule motors
tau neurofibrillary tangles
neurodegeneration

Experimental organism
D. melanogaster
mammalian cell culture
Benjamin L Parker

University of Melbourne, Australia

Expertise
Cell Biology
Computational and Systems Biology
Biochemistry and Chemical Biology

Research focus
proteomics
signal transduction
metabolism
skeletal muscle
exercise
insulin resistance
phosphorylation
protein post-translational modifications
Candie Paulsen

Yale University, United States

Expertise
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
Neuroscience

Research focus
ion channels
TRP channels
ligand-gated ion channels
calcium regulation
membrane protein structural biology
cryo-EM of ion channels and membrane proteins
pain signaling
redox biology
signal transduction
Camilo Perez

University of Georgia, United States

Expertise
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics

Research focus
membrane proteins
transporters
structural biology
bacteria
cell wall
Jon Pines

Institute of Cancer Research, University College London, United Kingdom

Expertise
Biochemistry and Chemical Biology
Cell Biology

Research focus
cyclins and anaphase promoting complex/cycosome (APC/C)
cell cycle
mitosis
spindle assembly checkpoint

Experimental organism
human
Stephan Pless

University of Copenhagen, Denmark

Expertise
Structural Biology and Molecular Biophysics
Biochemistry and Chemical Biology

Research focus
ion channels
pharmacology
electrophysiology
biophysics
chemical biology
non-canonical amino acids
protein engineering
neurobiology
Owen Pornillos

University of Virginia, United States

Expertise
Microbiology and Infectious Disease
Structural Biology and Molecular Biophysics
Biochemistry and Chemical Biology

Research focus
higher-order assembly
cell-free reconstitution
retrovirus structure
tripartite motif proteins
Alejandro San Martín

Centro de Estudios Científicos and Universidad San Sebastián, Chile

Expertise
Biochemistry and Chemical Biology
Cancer Biology
Cell Biology

Research focus
imaging
metabolism
FRET
single-fluorophore
single-cell
cell physiology
optogenetics
Rajan Sankaranarayanan

CSIR – Centre for Cellular and Molecular Biology, India

Expertise
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics

Research focus
crystal structure
mechanism
translation of genetic code
proofreading
editing
tRNA synthetase

Experimental organism
E. coli
Shimon Schuldiner

The Hebrew University of Jerusalem, Israel

Expertise
Biochemistry and Chemical Biology
Microbiology and Infectious Disease

Research focus
ion-coupled transporters
neurotransporters
multidrug transporters
vesicular transporters
antibiotic resistance
bioenergetics
microbial physiology
membrane proteins
Marcus M Seldin

University of California, Irvine, United States

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Genetics and Genomics

Research focus
systems genetics
endocrine physiology
metabolism
cell-cell communication
James R Sellers

National Heart, Lung and Blood Institute, National Institutes of Health, United States

Expertise
Biochemistry and Chemical Biology
Cell Biology
Developmental Biology

Research focus
myosin
Akira Shinohara

Osaka University, Japan

Expertise
Biochemistry and Chemical Biology
Chromosomes and Gene Expression
Cell Biology

Research focus
recombination
DSB repair
meiosis
chromosome
DNA damage response

Experimental organism
S. cerevisiae
human
mouse
Show-Ling Shyng

Oregon Health and Science University, United States

Expertise
Biochemistry and Chemical Biology
Cell Biology
Structural Biology and Molecular Biophysics

Research focus
ion channels
protein structure-function
electrophysiology
pharmacology
intracellular trafficking
signal transduction
chaperones
islet biology
Sloan Siegrist

University of Massachusetts Amherst, United States

Expertise
Biochemistry and Chemical Biology
Microbiology and Infectious Disease

Research focus
mycobacteria
chemical biology
membranes
antibiotics
cell envelope
Judith Simcox

University of Wisconsin-Madison, United States

Expertise
Biochemistry and Chemical Biology
Cell Biology
Chromosomes and Gene Expression

Research focus
lipidomics
metabolic disease
molecular biology
lipid metabolism
fatty acids
Amit Singh

Indian Institute of Science , India

Expertise
Microbiology and Infectious Disease
Biochemistry and Chemical Biology

Research focus
HIV
redox
metabolism
mycobacterium tuberculosis
mitochondria
biosensors
metals
antimicrobial resistance
bacterial persistence
Fe-S clusters
Jungsan Sohn

Johns Hopkins University School of Medicine, United States

Expertise
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
Immunology and Inflammation
Microbiology and Infectious Disease

Research focus
innate immunity
inflammasomes
X-ray crystallography
cryo-EM
biochemistry
enzyme kinetics
Jonathan S Stamler

Case Western Reserve University, United States

Expertise
Medicine
Biochemistry and Chemical Biology

Research focus
S-nitrosylation
nitric oxide
redox
redox-signaling
cysteine
thiols
N. Ravi Sundaresan

Indian Institute of Science, India

Expertise
Cell Biology
Medicine
Biochemistry and Chemical Biology
Chromosomes and Gene Expression
Stem Cells and Regenerative Medicine

Research focus
reversable acetylation
ADP-ribosylation
cellular senescence and aging
sirtuins
cardiac and skeletal muscle diseases
fibrosis

Experimental organism
human
mouse
rat
Alan Talevi

National University of La Plata, Argentina

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Microbiology and Infectious Disease
Structural Biology and Molecular Biophysics

Research focus
bioinformatics
drug discovery
cheminformatics
pharmacy
Ivan Topisirovic

Jewish General Hospital, Canada

Expertise
Biochemistry and Chemical Biology
Cancer Biology
Cell Biology

Research focus
mRNA translation
signaling
metabolic regulation
protein quality control

Experimental organism
mouse
human
Mohamed Trebak

University of Pittsburgh School of Medicine, United States

Expertise
Structural Biology and Molecular Biophysics
Cell Biology
Biochemistry and Chemical Biology

Research focus
calcium channels
receptor signalling
ion channel regulation
vascular remodeling
smooth muscle
Julie P I Welburn

University of Edinburgh, United Kingdom

Expertise
Biochemistry and Chemical Biology
Cell Biology
Structural Biology and Molecular Biophysics

Research focus
mitosis
cytoskeleton
motors
phosphorylation
kinase
microtubule
cilia
kinetochore

Experimental organism
human
in vitro
R Luke Wiseman

Scripps Research, United States

Expertise
Biochemistry and Chemical Biology
Cell Biology

Research focus
proteostasis
stress-responsive signaling
unfolded protein response
protein secretion
mitochondria regulation
small molecule development
Jie Xiao

Johns Hopkins University, United States

Expertise
Biochemistry and Chemical Biology
Cell Biology
Chromosomes and Gene Expression
Microbiology and Infectious Disease
Physics of Living Systems
Structural Biology and Molecular Biophysics

Research focus
single molecule biophysics
microbiology
cell division
cell wall
gene expression

Experimental organism
E. coli
Keqiang Ye

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China

Expertise
Medicine
Cancer Biology
Biochemistry and Chemical Biology
Neuroscience

Research focus
neuroscience
molecular cytobiology
cancer biology
neurodegenerative disease

Experimental organism
mouse
Qing Zhang

University of Texas Southwestern Medical Center, United States

Expertise
Cancer Biology
Biochemistry and Chemical Biology

Research focus
CRISPR
cancer metabolism
hypoxia
kidney cancer
breast cancer
epigenetics
post-translational modifications
synthetic lethality
Yu Zhao

Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, China

Expertise
Biochemistry and Chemical Biology
Cancer Biology
Chromosomes and Gene Expression
Genetics and Genomics

Research focus
prostate cancer
noncoding RNA
m6A
epigenetics
enhancer
DNA damage
senescence
radiotherapy