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    1. Neuroscience

    Researchers identify new therapeutic strategy for fentanyl overdose

    Blocking peripheral opioid receptors with naloxone methiodide sufficiently prevents and reverses fentanyl-induced cardiorespiratory depression without causing the aversive effects of naloxone in rodents.
    1. Stem Cells and Regenerative Medicine

    Study reveals breakthrough in reversing age-related decline in bone healing

    Combining intermittent fasting with localised Wnt3a treatments can rejuvenate bone repair in older mice, offering hope for reversing age-related tissue decline.
    1. Microbiology and Infectious Disease

    Study shows how genetic defects in Toxoplasma are rescued by co-infection

    Toxoplasma gondii parasites can use secreted factors to compensate for genetic defects in neighbouring parasites, highlighting a limitation of pooled CRISPR screens.
    1. Neuroscience

    Scientists identify brain cell type as master controller of urination

    A subset of cells in the brain coordinate bladder muscle and sphincter function to precisely control urination, according to new research.
    1. Microbiology and Infectious Disease

    New tool reveals how malaria sticks to red blood vessels

    A new gene-editing tool enables precise study of the variable proteins that allow malaria parasites to stick to red blood cells and evade the immune system.
    1. Neuroscience
    2. Physics of Living Systems

    Computational method pinpoints how cause-and-effect relationships ebb and flow over time

    A new computer model can more accurately assess how causal relationships in complex real-world systems vary over time.

  7. Media Coverage: September roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in September 2024, including Earth.com, Women’s Health and CT24.
    1. Neuroscience

    Study shows how social observation shapes decision making

    Researchers have investigated how people adjust their risk-taking behaviours while being observed, providing new insights into the nuanced ways social context influences decision making.
    1. Neuroscience
    2. Epidemiology and Global Health

    Study highlights complexity of menopausal hormone therapy’s impact on brain health

    A large UK study finds that the effects of menopausal hormone therapy on female brain health might vary depending on the duration of use and history of gynaecological surgery.
    1. Ecology

    Arthropods dominate plant litter decomposition in drylands

    An analysis of leaf litter breakdown in climatically diverse habitats shows that decomposition by larger invertebrates dominates in hot, dry regions and warmer seasons.
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