Cell Biology

Cell Biology

eLife reviews research spanning vesicle transport and signal transduction to cell cycle and cell polarity and fate. Learn more about what we review and sign up for the latest content.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Cancer Biology

    RUNX2 Isoform II Protects Cancer Cells from Ferroptosis and Apoptosis by Promoting PRDX2 Expression in Oral Squamous Cell Carcinoma

    Junjun Huang, Rong Jia, Jihua Guo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology
    2. Cancer Biology

    DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

    Simar Pal Singh, Michelle D van den Beukel ... Annemiek B van Spriel
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes

    Sakshi Shambhavi, Sudipta Mondal ... Rajan Sankaranarayanan
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cancer Biology
    2. Cell Biology

    Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Cell crowding drives a pro-invasive mechanotransduction pathway in high-grade DCIS, inducing TRPV4 inhibition, calcium and cell volume reduction, and increased invasion, with compensatory plasma-membrane TRPV4 relocation indicating pathway activation.
    1. Cancer Biology
    2. Cell Biology

    Breast Cancer: How cell crowding causes cancer cells to spread

    Rui Hua, Jean X Jiang
    Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread.
    Version of Record
    Insight
    1. Cell Biology
    2. Neuroscience

    Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

    Masaya Muramoto, Nozomi Hanawa ... Natsuki Shinoda
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Diet-induced obesity, insulin resistance, and proinflammatory macrophage activation and accumulation in adipose tissue can be counteracted through the inhibition of ER stress sensor IRE1alpha.
    1. Cell Biology

    TRPγ regulates lipid metabolism through Dh44 neuroendocrine cells

    Dharmendra Kumar Nath, Subash Dhakal, Youngseok Lee
    TRPγ is essential for maintaining lipid homeostasis in Drosophila melanogaster, linking neuronal regulation to fat metabolism and suggesting potential therapeutic avenues for metabolic disorders.
    1. Cell Biology
    2. Neuroscience

    Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

    Moloy T Goswami, Eric Weh ... Thomas J Wubben
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cell Biology

    Nim1-related kinases regulate septin organization and cytokinesis by modulating Hof1 at the cell division site

    Bindu Bhojappa, Anubhav Dhar ... Saravanan Palani
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete

Highlights

    1. Cancer Biology
    2. Cell Biology

    Cell crowding and cancer

    Rui Hua, Jean X Jiang
    1. Cell Biology
    2. Medicine

    Exploring hypertension

    Wadih EI Khoury, Stephen Y Chan
    1. Cell Biology
    2. Developmental Biology

    Looking at lens development

    Sarah Y Coomson, Salil A Lachke

Senior editors

  1. Sofia J Araújo
    University of Barcelona, Spain
  2. Felix Campelo
    The Institute of Photonic Sciences, Spain
  3. Silke Hauf
    Virginia Tech, United States
  4. See more editors