Insights

Latest articles

1. 1. Developmental Biology
   2. Genetics and Genomics

   Vascular Development: Enhancing our understanding of endothelial cells

   Guillermo Luxán

   What determines whether an endothelial cell becomes part of an artery, a vein or a capillary?
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Cellular Energy Production: Mycofactocin and the mycobacterial electron transport chain

   Stephanie M Stuteley, Ghader Bashiri

   In the bacterium M. smegmatis, an enzyme called MftG allows the cofactor mycofactocin to transfer electrons released during ethanol metabolism to the electron transport chain.
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Transcription: The plusses and minuses of DNA torsion

   Steven Henikoff, David L Levens

   A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.
4. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Neurodegeneration: A role for RNA knots in Alzheimer’s disease

   Silvia Galli, Marco Di Antonio

   The buildup of knot-like RNA structures in brain cells may be the key to understanding how uncontrolled protein aggregation drives Alzheimer’s disease.
5. 1. Developmental Biology

   Morphogenesis: Fluid transport comes to the fore

   Yufei Wu, Sean X Sun

   Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
6. 1. Developmental Biology
   2. Neuroscience

   Axon Guidance: Watching axons on the move

   Maria I Lazaro-Pena, Carlos A Diaz-Balzac

   The ligand Netrin mediates axon guidance through a combination of haptotaxis over short distances and chemotaxis over longer distances.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Drug Discovery: How to exploit the recycling system of a cell

   Sasha L Evans, Bethany A Haynes ... Rivka L Isaacson

   Nature has inspired the design of improved inhibitors for cancer-causing proteins.
8. 1. Cell Biology

   Beta Cells: Opportunity makes a hub or a leader

   Marjan Slak Rupnik

   Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.
9. 1. Evolutionary Biology
   2. Neuroscience

   Vision: The inner workings of a miniature eye

   Gregor Belušič

   The first complete 3D reconstruction of the compound eye of a minute wasp species sheds light on the nuts and bolts of size reduction.
10. 1. Neuroscience

    Pain-Related Memory Impairment: How does chronic pain lead to memory loss?

    Suelen Pereira, Ivan Tomsic ... Mychael V Lourenco

    A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.