Medicine

Latest articles

1. 1. Cell Biology
   2. Medicine

   Long non-coding RNA Malat1 fine-tunes bone homeostasis and repair by orchestrating cellular crosstalk and β-catenin-OPG/Jagged1 pathway

   Yongli Qin, Jumpei Shirakawa ... Baohong Zhao

   Malat1 is a key skeletal regulator, unveiling how lncRNAs integrate cellular crosstalk and molecular networks to regulate bone remodeling and regeneration, establishing a novel paradigm in tissue homeostasis and repair.
2. 1. Computational and Systems Biology
   2. Medicine

   Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

   Xin Zhou, Zhinuo Jenny Wang ... Blanca Rodriguez

   Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
3. 1. Medicine
   2. Microbiology and Infectious Disease

   The effect of combining antibiotics on resistance: A systematic review and meta-analysis

   Berit Siedentop, Viacheslav N Kachalov ... Sebastian Bonhoeffer

   A systematic review shows no evidence of harm or benefit of antibiotic combinations on resistance evolution as clinical data lack statistical power to draw definitive conclusions, highlighting a knowledge gap.
4. 1. Medicine

   A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model

   Mitsuru Sugimoto, Tadayuki Takagi ... Hiromasa Ohira
5. 1. Cell Biology
   2. Medicine

   Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

   Judith Hüttemeister, Franziska Rudolph ... Michael Gotthardt

   Titin’s regulated integration and mobility after cell fusion support syncytium formation in culture, while limited diffusion in vivo highlights a key challenge for developing effective cell-based therapies for skeletal muscle diseases.
6. 1. Medicine
   2. Neuroscience

   Cold induces brain region-selective cell activity-dependent lipid metabolism

   Hyeonyoung Min, Yale Y Yang, Yunlei Yang
7. 1. Cell Biology
   2. Medicine

   Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in Mice

   Shuo He, Lei Huang ... Jinlong He
8. 1. Medicine
   2. Neuroscience

   Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain

   Chi Zhang, Qian Huang ... Yun Guan

   The naturally occurring biologics, FLO and HC-HA/PTX3, derived from human birth tissues, may be developed as a much-needed non-opioid therapy for post-surgical pain treatment, leveraging robust neuronal mechanisms.
9. 1. Medicine

   Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies

   Sami Fawaz, Severine Marti ... Thierry Couffinhal

   If CHIP and mLOY do not significantly contribute to inflammation, atherosclerosis or myocardial infarction risk independently, CHIP may increase the risk of MI in men who do not carry mLOY.
10. 1. Medicine

    Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial

    Feilin Cao, Zhaosheng Ma ... Shifen Huang