Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Global analyses using aneuploid Drosophila revealed the dynamic roles of RNA m6A modification in regulating gene expression and development under genomic imbalance, highlighting its potential relationships with dosage-related effects.
In feedforward networks with random connectivity, connection motifs underlying the detection of short clusters and activity sequences are likely to converge on a subset of postsynaptic neurons purely by chance.
Numerous related sample characteristics affect polygenic score performance, and incorporation of interaction effects increases both model and polygenic score performance.
Geoffrey W Meissner, Allison Vannan ... FlyLight Project Team
Thousands of cell-type-specific split-GAL4 driver lines and a massive, searchable image collection enable Drosophila neuroscientists to target neurons of interest with increased precision.
Sharon Inberg, Yael Iosilevskii ... Benjamin Podbilewicz
Mechanosensory isolation of C. elegans nematodes independently induces homeostatic structural changes in the dendritic tree and differential response to mechanical stimulation, both these structural and behavioral outcomes are mediated by degenerins and do not affect presynaptic calcium dynamics.
Confocal and electron microscopy analyses reveal that contextual fear extinction induces structural remodeling of thalamic projections to the CA1 area of the hippocampus.
Tirso RJ Gonzalez Alam, Katya Krieger-Redwood ... Elizabeth Jefferies
Default mode network and visual cortex are connected via two parallel pathways that differentially respond to the processing of visual scenes and semantic information about objects, reflecting domain-specific organisation.
Psychophysical experiments and computational modeling demonstrate the importance of transient, instead of sustained, channels for the integration of audiovisual signals.
A novel meta-analytical method aggregating five SST datasets does not find evidence for the innervation of the hyperdirect or indirect cortico-basal-ganglia pathways in successful response inhibition.
Patsy R Tomlinson, Rachel G Knox ... Robert K Semple
PIK3R1 mutations that cause immunodeficiency through PI3-kinase hyperactivation also cause SHORT syndrome, due to PI3-kinase hypofunction, attributable to PI3-kinase destabilisation and outcompetition by mutant PIK3R1.
