Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Masahiro Takigawa, Marta Huelin Gorriz ... Daniel Bendor
A novel tool enables cross-checking the quality of replay events and evaluating the effectiveness of a given replay detection method in the absence of a ground truth.
Bethany M Bartlett, Yatendra Kumar ... Wendy A Bickmore
Evidence is provided suggesting that heterochromatin re-organisation during cell senescence can compromise the structural integrity of the nucleus, leading to activation of an inflammatory process.
Pénélope Tignard, Karen Pottin ... Marie Anne Breau
Laminin gamma1-dependent basement membranes are required for multiple aspects of olfactory system development in zebrafish, including the maintenance of placode tissue shape and the growth of the olfactory axons.
Malat1 is a key skeletal regulator, unveiling how lncRNAs integrate cellular crosstalk and molecular networks to regulate bone remodeling and regeneration, establishing a novel paradigm in tissue homeostasis and repair.
Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
Downregulation of PTBP1 in neurons, but not astrocytes, alleviates motor symptoms in a Parkinson’s disease mouse model by inducing dopaminergic marker expression in striatal neurons and increasing striatal dopamine levels.
Xiaoqian Yan, Sarah Shi Tung ... Kalanit Grill-Spector
Scalp electroencephalography combined with a frequency tagging method reveals that distinct responses to daily categories emerge at different ages in infants.
Genome dilution limits cell growth by modulating the activities, rather than the concentrations, of RNA polymerases and ribosomes, and is accompanied by changes in proteome composition.
