Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression

    SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing

    Ashwin Govindan, Nicholas K Conrad
    SFSWAP was identified in a genetic screen to negatively regulate splicing of OGT and other mRNAs primarily by regulating intron retention and exon skipping.
    1. Chromosomes and Gene Expression

    Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation

    Qianyun Fu, Terry Nguyen ... Y George Zheng
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair

    Artem K Velichko, Nadezhda V Petrova ... Omar L Kantidze
    Treacle condensation, driven by alternating charge blocks, facilitates interactions with transcription factors to spatially segregate ribosomal RNA synthesis and processing, while also recruiting TOPBP1 for activation of the rDNA damage response.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    A mathematical model clarifies the ABC Score formula used in enhancer-gene prediction

    Joseph Nasser, Kee-Myoung Nam, Jeremy Gunawardena
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Broad-spectrum immune suppression encoded in self-amplifying RNA enables non-cytotoxic, non-immunostimulatory, externally controllable transgene expression

    Tony KY Lim, Anne Ritoux ... Ewan St John Smith
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations

    Lucas Inchausti, Lucía Bilbao ... Pablo Smircich
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Solid
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

    Gülnihal Kavaklioglu, Alexandra Podhornik ... Christian Seiser
    DNA hypomethylation in human tumor cells results in the activation of the LINE-1-derived RNA-binding protein L1TD1 and its interactions with LINE-1 transposons.
    1. Chromosomes and Gene Expression

    Acute Activation of Genes Through Transcriptional Condensates Impact Non-target Genes in a Chromatin Domain

    Darshika Bohra, Zubairul Islam ... Dimple Notani
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

    Antara Sengupta, Soujanya Vinayagamurthy ... Shantanu Chowdhury
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous samples

    Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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Highlights

    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Navigating the secrets of COMPASS

    Karolin Luger, Jonathan W Markert
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Reality check for transposons

    Julie Brind'Amour, Dixie L Mager
    1. Chromosomes and Gene Expression

    Painting chromosomes in the nucleus

    Cori K Cahoon, Diana E Libuda

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Silke Hauf
    Virginia Tech, United States
  3. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  4. See more editors