Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genetic stability of Mycobacterium smegmatis under the stress of first-line antitubercular agents

    Dániel Molnár, Éva Viola Surányi ... Judit Toth
    A combined approach of genome sequencing and fluctuation assays shows that antibiotic pressure does not induce adaptive mutations in Mycobacterium smegmatis, supporting drug resistance as a consequence of phenotypic tolerance.
    1. Genetics and Genomics
    2. Medicine

    Single-cell characterization of menstrual fluid at homeostasis and in endometriosis

    Petra C Schwalie, Cemsel Bafligil ... Angela Goncalves
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model

    Arkadiy K Golov, Alexey A Gavrilov ... Sergey V Razin
    Revised
    Reviewed Preprint v2
    Updated
    1. Cell Biology
    2. Genetics and Genomics

    Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

    Breanna Lam, Kathrin M Kajderowicz ... Sinisa Hrvatin
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Evolutionary Biology

    The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

    Xiaopei Wang, Yongsen Ruan ... Haijun Wen
    Revised
    Reviewed Preprint v2
    Updated
    1. Genetics and Genomics

    Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors

    Ximena Corso-Díaz, Xulong Liang ... Anand Swaroop
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Genetics and Genomics

    Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress

    Showkat A Dar, Sulochan Malla ... Manolis Maragkakis
    Revised
    Reviewed Preprint v2
    Updated
    1. Genetics and Genomics
    2. Cancer Biology

    Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals

    Yaroslav Kainov, Fursham Hamid, Eugene V Makeyev
    Revised
    Reviewed Preprint v2
    Updated
    1. Developmental Biology
    2. Genetics and Genomics

    Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability

    Ignacy Czajewski, Bijayalaxmi Swain ... Daan MF van Aalten
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Functional characteristics and computational model of abundant hyperactive loci in the human genome

    Sanjarbek Hudaiberdiev, Ivan Ovcharenko
    Large-scale multi-omics analysis of genomic high-occupancy target regions in humans suggests involvement of large transcriptional condensates.
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Highlights

    1. Cancer Biology
    2. Genetics and Genomics

    Cancer: Predicting drug resistance

    Nicole S Arellano, Shannon E Elf
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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    1. Genetics and Genomics
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Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Yamini Dalal
    National Cancer Institute, United States
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