Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics
    2. Evolutionary Biology

    Lifestyles shape genome size and gene content in fungal pathogens

    Anna Fijarczyk, Pauline Hessenauer ... Christian R Landry
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics

    Molecular Requirements for C. elegans Transgenerational Epigenetic Inheritance of Pathogen Avoidance

    Rachel Kaletsky, Rebecca Moore ... Coleen T Murphy
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Genetics and Genomics

    UBR-1 deficiency leads to ivermectin resistance in Caenorhabditis elegans

    Yi Li, Long Gong ... Shangbang Gao
    Behavioral and functional analyses revealed that UBR-1 deficiency in Caenorhabditis elegans disrupts glutamate signaling and confers ivermectin resistance.
    1. Genetics and Genomics
    2. Neuroscience

    Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

    Jiro Yoshino, Sonali S Mali ... Jay Z Parrish
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Evolutionary Biology

    Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary classification of sexes

    Chen Xie, Sven Künzel, Diethard Tautz
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cell Biology
    2. Genetics and Genomics

    Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma

    Keva Li, Nicholas Tolman ... UK Biobank Eye and Vision Consortium
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics

    Dimeric R25CPTH(1–34) activates the parathyroid hormone-1 receptor in vitro and stimulates bone formation in osteoporotic female mice

    Minsoo Noh, Xiangguo Che ... Sihoon Lee
    A novel mutant, R25CPTH, derived from a hypoparathyroidism patient, can form a dimer that activates PTH1R and enhances bone formation in female mice similar to PTH despite altered molecular properties.
    1. Developmental Biology
    2. Genetics and Genomics

    Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

    Menglei Yang, Hafiz Muhammad Jafar Hussain ... Baolu Shi
    DNAH12 is essential for sperm flagellar development and male fertility in both humans and mice by interacting with dynein proteins DNAH1 and DNALI1.
    1. Genetics and Genomics

    Reported transgenerational responses to Pseudomonas aeruginosa in Caenorhabditis elegans are not robust

    Daniel Patrick Gainey, Andrey V Shubin, Craig P Hunter
    The failure to replicate key findings from an important report on transgenerational inheritance in Caenorhabditis elegans raises concerns about the robustness and ecological significance of the previously reported results.
    1. Genetics and Genomics

    Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function

    Omid Gholamalamdari, Tom van Schaik ... Andrew S Belmont
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
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    3. Genetics and Genomics

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    1. Genetics and Genomics

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Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Yamini Dalal
    National Cancer Institute, United States
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
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