Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

   Josep Fita-Torró, José Luis Garrido-Huarte ... Markus Proft
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   A General Mechanism for Initiating the General Stress Response in Bacteria

   Rishika Baral, Kristin Ho ... Niels Bradshaw
3. 1. Biochemistry and Chemical Biology

   Enzymatic protein fusions with 100% product yield

   Adrian CD Fuchs

   This enzymatic method enables highly specific and complete 1:1 protein conjugations with small molecules, solid supports, and other proteins, offering broad applicability across diverse biochemical and biotechnological applications.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

   Joar Esteban Pinto Torres, Mathieu Claes ... Yann G-J Sterckx

   A camelid single-domain antibody potently and specifically inhibits pyruvate kinases from trypanosomatids.
5. 1. Biochemistry and Chemical Biology

   Decoding m⁶Am by simultaneous transcription-start mapping and methylation quantification

   Jianheng Fox Liu, Ben R Hawley ... Samie R Jaffrey

   CROWN-seq provides the first precise and quantitative map of N⁶,2’-O-dimethyladenosine (m⁶Am) in mRNA and snRNA, revealing the link between m⁶Am modification and efficient transcription, rather than translation and RNA stability.
6. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase

   Eva Herdering, Tristan Reif-Trauttmansdorff ... Ruth Anne Schmitz

   The central nitrogen-metabolite 2-oxoglutarate directly promotes glutamine synthetase activity by inducing its dodecameric assembly and priming the active sites, representing a novel mechanism of regulation.
7. 1. Biochemistry and Chemical Biology

   Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation: relevance in cancer prognosis

   Nelson García-Vázquez, Tania J González-Robles ... Michele Pagano
8. 1. Biochemistry and Chemical Biology

   Induction of hepatitis B core protein aggregation targeting an unconventional binding site

   Vladimir Khayenko, Cihan Makbul ... Hans Michael Maric

   Targeting two novel sites on the hepatitis B virus capsid disrupts its assembly and induces aggregation, suggesting potential for antiviral therapy development.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   AI-based discovery and cryoEM structural elucidation of a K_ATP channel pharmacochaperone

   Assmaa Elsheikh, Camden M Driggers ... Show-Ling Shyng

   Structure-based approach identifies a K_ATP-binding compound that has the potential of normalizing insulin secretion in congenital hyperinsulinism by correcting defective K_ATP channel trafficking to the cell surface.
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Microphase separation produces interfacial environment within diblock biomolecular condensates

    Andrew P Latham, Longchen Zhu ... Bin Zhang

    The microenvironment within biomolecular condensates exhibits interfacial behaviors characterized by a combination of hydrophobic and hydrophilic properties.