Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Teichoic acids in the periplasm and cell envelope of Streptococcus pneumoniae

    Mai Nguyen, Elda Bauda ... Cecile Morlot
    The thickness of the periplasmic region is reduced in strains of pneumococcus that are deleted in genes responsible for the incorporation of teichoic acid in the cell envelope.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome

    Rohan Eapen, Cynthia Okoye ... Laura S Itzhaki
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Shinichi Kawaguchi, Xin Xu ... Toshie Kai
    AlphaFold2-based large-scale screening reveals novel protein interactions, accelerating functional studies of piRNA pathway proteins and expanding bioinformatic-experimental integration.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

    Yamato Niitani, Kohei Matsuzaki ... Michio Tomishige
    Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along microtubules.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

    Laura S Kremer, Guanbin Gao ... Nils-Göran Larsson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Phage-displayed synthetic library and screening platform for nanobody discovery

    Baolong Xia, Ah-Ram Kim ... Norbert Perrimon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

    A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
    Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Mapping the functional landscape of >6600 MC4R variants via deep mutational scanning reveals novel determinants of biased signaling and ligand interactions that inform targeted obesity therapeutics.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

    Jiale Zhou, Ding Zhao ... Zhanjun Li
    The DRAM system enables antibody-free, bisulfite-free, and transcriptome-wide mapping of 5-methylcytosine in mRNA with high accuracy, stability, and sensitivity, even at ultralow RNA inputs.

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Merritt Maduke
    Stanford University School of Medicine, United States
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