Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Control of 3ʹ splice site selection by the yeast splicing factor Fyv6

    Katherine A Senn, Karli A Lipinski ... Aaron A Hoskins
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Identification of Suitable Target/E3 Ligase Pairs for PROTAC Development using a Rapamycin-induced Proximity Assay (RiPA)

    Bikash Adhikari, Katharina Schneider ... Elmar Wolf
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology

    The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules and transports double-strand DNA

    Shinsuke Niwa, Natsuki Furusaki ... Kyoko Chiba
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

    Eyal Paz, Sahil Jain ... Abdussalam Azem
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conformational fingerprint for amyloidogenic light chains

    Cristina Paissoni, Sarita Puri ... Carlo Camilloni
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Disordered proteins interact with the chemical environment to tune their protective function during drying

    Shraddha KC, Kenny H Nguyen ... Thomas C Boothby
    The ability of intrinsically disordered proteins to protect sensitive enzymes during drying can be tuned through interactions with cosolutes.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage

    Joanna Krwawicz, Caroline J Sheeba ... Peter Sarkies
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Kawaguchi Shinichi, Xu Xin ... Kai Toshie
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

    Amrita Rai, Petra Janning ... Roger S Goody
    Not revised
    Reviewed Preprint v1
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. David James
    University of Sydney, Australia
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
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