Short Reports

A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.

Latest articles

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

    A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
    Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Neuroscience

    A novel method (RIM-Deep) for enhancing imaging depth and resolution stability of deep cleared tissue in inverted confocal microscopy

    Yisi Liu, Pu Wang ... Hongwei Zhou
    RIM-Deep enhances imaging depth in confocal microscopy enabling high-quality visualization of large cleared samples across various fields with minimal cost.
    1. Immunology and Inflammation

    Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation

    Jian Cui, Hua Li ... Congqing Wu
    Procoagulant microvesicles derived from ruptured immune cells fuel blood coagulation.
    1. Cancer Biology
    2. Immunology and Inflammation

    Unraveling the power of NAP-CNB’s machine learning-enhanced tumor neoantigen prediction

    Almudena Mendez-Perez, Andres M Acosta-Moreno ... Esteban Veiga
    NAP-CNB, a machine learning platform, accurately identifies tumor neoantigens, where higher tumor expression correlates with optimal antitumor activity, and multiantigen vaccination enhances immune responses.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Neuroscience

    Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm

    Sergio Casas-Tinto, Nuria Garcia-Guillen, María Losada-Perez
    Genetic and lineage-tracing analyses reveal that neuropil-associated glia can directly transdifferentiate into neurons in the adultcentral nervous system (CNS) after injury, uncovering a previously unrecognised mechanism for CNS regeneration.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Secondary structure of the SARS-CoV-2 genome is predictive of nucleotide substitution frequency

    Zach Hensel
    SARS-CoV-2 secondary structure shapes mutation frequencies, constraining viral evolution models predicting fitness can benefit from integrating secondary structure data.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Neuroscience

    Characterization of direct Purkinje cell outputs to the brainstem

    Christopher H Chen, Zhiyi Yao ... Wade G Regehr
    Cerebellar Purkinje cells make direct synapses within the parabrachial, vestibular, pontine central gray, and other brainstem nuclei that exhibit spatial gradients and cell specificity consistent with nuanced influences on diverse behaviors.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Cell Biology

    A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)

    Tamás Visnovitz, Dorina Lenzinger ... Edit I Buzas
    A novel 'torn bag mechanism' is described for the release of LC3 positive and negative small extracellular vesicles (exosomes) from amphiectosomes.
    Version of Record
    Short Report
    • Important
    • Compelling
    1. Neuroscience

    Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration

    Xing Xiao, Gagik Yeghiazaryan ... Anne Christine Hausen
    Ox1R signaling in dopaminergic neurons regulates context-induced locomotor activity and exploration in mice.
    Version of Record
    Short Report
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    A new pipeline SPICE identifies novel JUN-IKZF1 composite elements

    Peng Li, Sree Pulugulla ... Warren J Leonard
    Computational pipeline SPICE systematically screens and predicts novel protein-protein binding complexes including the previously unrecognized global association and functional cooperation between IKZF1 and AP1.
    Version of Record
    Short Report
    • Valuable
    • Incomplete