Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Atomistic Simulation of Voltage Activation of a Truncated BK Channel

    Zhiguang Jia, Jianhan Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

    Jessica A Haley, Tianyi Chen ... Sreekanth H Chalasani
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology

    SCellBOW: AI-Driven Tumor Risk Stratification from Single-Cell Transcriptomics Using Phenotype Algebra

    Namrata Bhattacharya, Anja Rockstroh ... Debarka Sengupta
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Exploiting fluctuations in gene expression to detect causal interactions between genes

    Euan Joly-Smith, Mir Mikdad Talpur ... Andreas Hilfinger
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Self-Other Generalisation Shapes Social Interaction and Is Disrupted in Borderline Personality Disorder

    Joseph M Barnby, Jen Nguyen ... Peter Fonagy
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Shinichi Kawaguchi, Xin Xu ... Toshie Kai
    AlphaFold2-based large-scale screening reveals novel protein interactions, accelerating functional studies of piRNA pathway proteins and expanding bioinformatic-experimental integration.
    1. Computational and Systems Biology
    2. Neuroscience

    Neural population dynamics underlying evidence accumulation in multiple rat brain regions

    Brian DePasquale, Carlos D Brody, Jonathan W Pillow
    A computational framework for combining neural and behavioral data to infer latent dynamics underlying decision-making reveals distinct accumulation dynamics in different brain regions in the rat.
    1. Neuroscience
    2. Computational and Systems Biology

    Switching perspective: Comparing ground-level and bird’s-eye views for bumblebees navigating dense environments

    Annkathrin Sonntag, Odile Sauzet ... Olivier Bertrand
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    Balancing reaction-diffusion network for cell polarization pattern with stability and asymmetry

    Yixuan Chen, Guoye Guan ... Chao Tang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors