Computational and Systems Biology

Latest articles

1. 1. Neuroscience
   2. Computational and Systems Biology

   Gain neuromodulation mediates task-relevant perceptual switches: evidence from pupillometry, fMRI, and RNN Modelling

   Gabriel Wainstein, Christopher J Whyte ... James M Shine
2. 1. Computational and Systems Biology

   The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth

   Lucas Fuentes Valenzuela, Paul Francois, Jan Skotheim
3. 1. Computational and Systems Biology

   Semantical and Geometrical Protein Encoding Toward Enhanced Bioactivity and Thermostability

   Yang Tan, Bingxin Zhou ... Liang Hong
4. 1. Computational and Systems Biology

   Permute-match tests: Detecting significant correlations between time series despite nonstationarity and limited replicates

   Alex E Yuan, Wenying Shou
5. 1. Computational and Systems Biology

   Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging

   Huiyong Cheng, Dawson Miller ... Qiuying Chen
6. 1. Computational and Systems Biology

   AI-enabled alkaline-resistant evolution of protein to apply in mass production

   Liqi Kang, Banghao Wu ... Liang Hong

   The Pro-PRIME model demonstrates the ability to engineer VHH antibody with unprecedented alkali resistance and enhanced affinity, enabling industrial applications under extreme conditions previously unattainable with natural proteins.
7. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability

   Jia-Ying Su, Yun-Lin Wang ... Chien-Ling Lin

   The UA-dinucleotide ratio in UTRs is negatively correlated with RNA stability both in the massively parallel reporter assay and in vivo, and is prevalent in fast-turnover genes.
8. 1. Neuroscience
   2. Computational and Systems Biology

   Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

   Aske L Ejdrup, Jakob K Dreyer ... Ulrik Gether
9. 1. Structural Biology and Molecular Biophysics
   2. Computational and Systems Biology

   Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

   Gabriel Monteiro da Silva, Kyle Lam ... Brenda M Rubenstein
10. 1. Computational and Systems Biology
    2. Medicine

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu

    Inhibiting c-Jun N-terminal kinase exerts a cross-tissue therapeutic effect on metabolic dysfunction induced by sucrose overconsumption in rats.