Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience
    2. Computational and Systems Biology

    MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features

    Sarah Benkeder, Son-Michel Dinh ... Jean-Christophe Comte
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Computational and Systems Biology

    Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

    Rosalyn W Sayaman, Masaru Miyano ... Mark LaBarge
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    An antimicrobial drug recommender system using MALDI-TOF MS and dual-branch neural networks

    Gaetan De Waele, Gerben Menschaert, Willem Waegeman
    It is possible to accurately recommend antimicrobial drugs from mass spectra using neural networks and large datasets, paving the way for more efficient clinical diagnostics.
    1. Computational and Systems Biology

    Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

    Dylan C Sarver, Muzna Saqib ... G William Wong
    Revised
    Reviewed Preprint v3
    Updated
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Functional characteristics and computational model of abundant hyperactive loci in the human genome

    Sanjarbek Hudaiberdiev, Ivan Ovcharenko
    Large-scale multi-omics analysis of genomic high-occupancy target regions in humans suggests involvement of large transcriptional condensates.
    1. Computational and Systems Biology

    Derivation and internal validation of prediction models for pulmonary hypertension risk assessment in a cohort inhabiting Tibet, China

    Junhui Tang, Rui Yang ... Yali Xu
    Prediction models for pulmonary hypertension based on a cohort inhabiting Tibet, China were established and validated.
    1. Computational and Systems Biology
    2. Cancer Biology

    BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

    Emilio Rios-Jimenez, Anoek Zomer ... Maria Alieva
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer

    Nayoung Kim, Sehhoon Park ... Myung-Ju Ahn
    Single-cell RNA sequencing of biopsy samples from advanced-stage lung cancer reveals tumor and immune cell features associated with response to immune checkpoint therapy.
    1. Neuroscience
    2. Computational and Systems Biology

    Adaptive Integration of Perceptual and Reward Information in an Uncertain World

    Prashanti Ganesh, Radoslaw M Cichy ... Rasmus Bruckner
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

    András Ecker, Daniela Egas Santander ... Michael W Reimann
    Not revised
    Reviewed Preprint v1
Load more

Highlights

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    1. Computational and Systems Biology

    International aspects of bioRxiv preprints

    Richard J Abdill, Elizabeth M Adamowicz, Ran Blekhman

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors