Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Medicine

   Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

   Xin Zhou, Zhinuo Jenny Wang ... Blanca Rodriguez

   Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
2. 1. Computational and Systems Biology

   Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

   Dylan C Sarver, Muzna Saqib ... G William Wong

   Mitochondrial respiration atlas reveals functional signatures of aging across diverse tissues and organ systems.
3. 1. Computational and Systems Biology

   Cellular Respiration: Mapping mitochondrial aging

   Alessandro Bitto

   Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how aging affects mitochondrial function in mice.
4. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Overflow metabolism originates from growth optimization and cellheterogeneity

   Xin Wang
5. 1. Developmental Biology
   2. Computational and Systems Biology

   Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the Drosophila embryo

   Hadel Al Asafen, Natalie M Clark ... Gregory T Reeves
6. 1. Computational and Systems Biology

   Predicting the effect of CRISPR-Cas9-based epigenome editing

   Sanjit Singh Batra, Alan Cabrera ... Yun S Song
7. 1. Computational and Systems Biology

   Statistical analysis supports pervasive RNA subcellular localization and alternative 3' UTR regulation

   Rob Bierman, Jui M Dave ... Julia Salzman

   Analysis of genome-wide spatial transcriptomics data reveals cell-type specific subcellular RNA localization, and a subset of genes show significantly high correlation between spatial patterning and 3' UTR length.
8. 1. Computational and Systems Biology

   MGPfact^XMBD: A Model-Based Factorization Method for scRNA Data Unveils Bifurcating Transcriptional Modules Underlying Cell Fate Determination

   Jun Ren, Ying Zhou ... Qiyuan Li
9. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   The physiological landscape and specificity of antibody repertoires are consolidated by multiple immunizations

   Lucia Csepregi, Kenneth Hoehn ... Sai T Reddy

   Systems analysis of antibody repertoires reveals that strong humoral responses lead to extensive B-cell overlap across multiple lymphoid organs, indicating physiological axes of B-cell migration and a direct correlation with antigen specificity.
10. 1. Computational and Systems Biology
    2. Developmental Biology

    Dynamic readout of the Hh gradient in the Drosophila wing disc reveals pattern-specific tradeoffs between robustness and precision

    Rosalío Reyes, Arthur D Lander, Marcos Nahmad

    Theoretical and experimental evidence that Hh signaling dynamics balances robust positioning and sharpness of different target genes in the Drosophila wing disc.