Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Risk factors affecting polygenic score performance across diverse cohorts

   Daniel Hui, Scott Dudek ... Marylyn D Ritchie

   Numerous related sample characteristics affect polygenic score performance, and incorporation of interaction effects increases both model and polygenic score performance.
2. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   PAbFold: Linear Antibody Epitope Prediction using AlphaFold2

   Jacob DeRoo, James S Terry ... Brian J Geiss
3. 1. Computational and Systems Biology
   2. Physics of Living Systems

   How cancer-associated fibroblasts promote T-cell exclusion in human lung tumors: a physical perspective

   Joseph Ackermann, Chiara Bernard ... Martine Ben Amar
4. 1. Computational and Systems Biology

   Efficient coding in biophysically realistic excitatory-inhibitory spiking networks

   Veronika Koren, Simone Blanco Malerba ... Stefano Panzeri
5. 1. Computational and Systems Biology
   2. Neuroscience

   Multisensory integration operates on correlated input from unimodal transient channels

   Cesare V Parise, Marc O Ernst

   Psychophysical experiments and computational modeling demonstrate the importance of transient, instead of sustained, channels for the integration of audiovisual signals.
6. 1. Neuroscience
   2. Computational and Systems Biology

   Self-other generalisation shapes social interaction and is disrupted in borderline personality disorder

   Joseph M Barnby, Jen Nguyen ... Peter Fonagy
7. 1. Cell Biology
   2. Computational and Systems Biology

   Unbiased identification of cell identity in dense mixed neural cultures

   Sarah De Beuckeleer, Tim Van De Looverbosch ... Winnok H De Vos

   Morphological profiling allows accurate identification of cell types in dense iPSC-derived cultures, allowing its use for quality control and differentiation monitoring.
8. 1. Computational and Systems Biology

   CausalXtract, a flexible pipeline to extract causal effects from live-cell time-lapse imaging data

   Franck Simon, Maria Colomba Comes ... Herve Isambert

   CausalXtract is a computational tool to discover causal effects, beyond classical Granger and Schreiber causality approaches, from live-cell imaging data for a range of fundamental and translational research applications.
9. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability

   Jia-Ying Su, Yun-Lin Wang ... Chien-Ling Lin
10. 1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Discovery of a heparan sulfate binding domain in monkeypox virus H3 as an anti-poxviral drug target combining AI and MD simulations

    Bin Zheng, Meimei Duan ... Peng Zheng

    The identification of a conserved α-helical domain in monkeypox virus H3 protein as critical for heparan sulfate binding unveils a novel therapeutic target, validated through AI and molecular dynamics simulations, offering potential for broad-spectrum antiviral development.