Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

    Balázs István Tóth, Bahar Bazeli ... Thomas Voets
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport

    Merissa Brousseau, Da Teng ... Katherine A Henzler-Wildman
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    PROTAC-induced protein structural dynamics in targeted protein degradation

    Kingsley Y Wu, Ta I Hung, Chia-en A Chang
    Multi-level molecular modeling reveals how PROTAC-induced protein structural dynamics of degradation machinery complexes promote ubiquitination processes.
    1. Structural Biology and Molecular Biophysics

    Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

    Jing Xue, Weizhong Zeng ... Youxing Jiang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Structure and Cl- Conductance Properties of the Open State of Human CFTR

    Zhi-Wei Zeng, Christopher E Ing, Régis Pomès
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Drug Discovery: How to exploit the recycling system of a cell

    Sasha L Evans, Bethany A Haynes ... Rivka L Isaacson
    Nature has inspired the design of improved inhibitors for cancer-causing proteins.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    Wide transition-state ensemble as key component for enzyme catalysis

    Gabriel E Jara, Francesco Pontiggia ... Dorothee Kern
    Computational and experimental evidence shows that the reaction catalyzed by adenylate kinase operates through a broad transition-state ensemble (TSE), utilizing protein conformational diversity to reduce activation entropy.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland

    Gabriel Magno de Freitas Almeida, Iker Arriaga ... Lotta-Riina Sundberg
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conformational fingerprint for amyloidogenic light chains

    Cristina Paissoni, Sarita Puri ... Carlo Camilloni
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting

    Yangyu Wu, Yangyang Yan ... Fred J Sigworth
    The well-studied Kv1.2 potassium ion channel is observed in a variety of states and conditions, to understand mechanisms of ion permeation, gating and block.
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Highlights

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Improving inhibitors

    Sasha L Evans, Bethany A Haynes ... Rivka L Isaacson
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu

Senior editors

  1. Felix Campelo
    The Institute of Photonic Sciences, Spain
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors