Browse our latest Structural Biology and Molecular Biophysics articles

Type II nuclear receptors do not always compete for a limiting pool of their obligate partner RXRa.

The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltransferase activity.

Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.

An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

The clinically approved BTK kinase active site inhibitors alter the conformational equilibrium of full-length BTK in distinct and unexpected ways.

NMR and clustering results show that N-terminal acetylation of α-syn enhances its binding to the neutral phospholipid lysophosphatidylcholine, thereby promoting its function of clustering synaptic vesicles.

CTFFIND5 estimates the thickness and tilt of cryogenic electron microscopy samples directly from the power spectrum of a single exposure.