Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Cell Biology

    TRPγ regulates lipid metabolism through Dh44 neuroendocrine cells

    Dharmendra Kumar Nath, Subash Dhakal, Youngseok Lee
    TRPγ is essential for maintaining lipid homeostasis in Drosophila melanogaster, linking neuronal regulation to fat metabolism and suggesting potential therapeutic avenues for metabolic disorders.
    1. Medicine

    Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

    Hyun Beom Song, Laura Campello ... Anand Swaroop
    Reserpine, previously identified through high-throughput screening in CEP290 retinal degeneration models, enhances photoreceptor survival in P23H rhodopsin retinal degeneration models, particularly in female rats, indicating its gene-agnostic and sex-specific effectiveness.
    1. Developmental Biology

    Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut

    Mengjie Li, Aiguo Tian, Jin Jiang
    The asymmetrically segregated Notch pathway inhibitor Numb is essential for intestinal stem cell self-renewal in adult Drosophila midguts when the stem cell niche signaling is compromised.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

    Ana Cristina Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
    Recognition of antigenic ligand by T-cell receptors is a nuanced process where mechanical force can be leveraged to diversify functional outcomes of different T-cells for the same ligand.
    1. Neuroscience

    Ethograms predict visual fear conditioning status in rats

    David C Williams, Amanda Chu ... Michael A McDannald
    A more complete, bidirectional relationship between fear conditioning and behavior is established when many behaviors are examined, as opposed to single behavior such as freezing.
    1. Neuroscience

    Respiratory and cardiac interoceptive sensitivity in the first two years of life

    Markus R Tünte, Stefanie Hoehl ... Ezgi Kayhan
    Infants are sensitive to their own respiration and heartbeat already in the first two years of life.
    1. Neuroscience

    Integration of sensory and fear memories in the rat medial temporal lobe

    Francesca S Wong, Alina B Thomas ... Nathan M Holmes
    The amygdala and perirhinal cortex work together to integrate sensory and emotional information under a range of different circumstances.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

    Chinmaya Jena, Saillesh Chinnaraj ... Nishad Matange
    Gene duplication in antibiotic-resistant bacteria mitigates elevated demand for expression, facilitating adaptation to antibiotics and alleviating costs of proteolytic instability of the drug target.
    1. Cell Biology

    A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

    Rachel Pudlowski, Lingyi Xu ... Jennifer T Wang
    Centriolar triplet microtubules are required for the formation and positioning of centriole substructures.
    1. Neuroscience

    Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

    Tanja Fuchsberger, Imogen Stockwell ... Ole Paulsen
    The reward signal dopamine modulates synaptic plasticity by increasing protein synthesis, revealing a potential molecular mechanism for long-term memory storage.