Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Neuroscience

    Ethograms predict visual fear conditioning status in rats

    David C Williams, Amanda Chu ... Michael A McDannald
    A more complete, bidirectional relationship between fear conditioning and behavior is established when many behaviors are examined, as opposed to single behavior such as freezing.
    1. Neuroscience

    Respiratory and cardiac interoceptive sensitivity in the first two years of life

    Markus R Tünte, Stefanie Hoehl ... Ezgi Kayhan
    Infants are sensitive to their own respiration and heartbeat already in the first two years of life.
    1. Neuroscience

    Integration of sensory and fear memories in the rat medial temporal lobe

    Francesca S Wong, Alina B Thomas ... Nathan M Holmes
    The amygdala and perirhinal cortex work together to integrate sensory and emotional information under a range of different circumstances.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

    Chinmaya Jena, Saillesh Chinnaraj ... Nishad Matange
    Gene duplication in antibiotic-resistant bacteria mitigates elevated demand for expression, facilitating adaptation to antibiotics and alleviating costs of proteolytic instability of the drug target.
    1. Cell Biology

    A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

    Rachel Pudlowski, Lingyi Xu ... Jennifer T Wang
    Centriolar triplet microtubules are required for the formation and positioning of centriole substructures.
    1. Neuroscience

    Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

    Tanja Fuchsberger, Imogen Stockwell ... Ole Paulsen
    The reward signal dopamine modulates synaptic plasticity by increasing protein synthesis, revealing a potential molecular mechanism for long-term memory storage.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Improved base editing and functional screening in Leishmania via co-expression of the AsCas12a ultra variant, a T7 RNA polymerase, and a cytosine base editor

    Nicole Herrmann May, Anh Cao ... Tom Beneke
    An optimized cytosine base editing system for Leishmania species improves editing efficiency, reduces toxicity, and ensures stable guide expression, enabling scalable loss-of-function screening and efficient creation of functional mutants.
    1. Developmental Biology

    Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish

    Wenqing Li, Sara McCurdy ... Mark H Ginsberg
    The β1 adrenergic receptor is a key regulator of cerebral cavernous malformation pathogenesis.
    1. Cell Biology

    Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis

    Shixuan Liu, Ceryl Tan ... Ran Kafri
    Oversized mammalian cells reduce their growth efficiency by activating global protein degradation, which functions in parallel with the cell size checkpoints, to promote cell size homeostasis.
    1. Structural Biology and Molecular Biophysics

    Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

    Parveen Goyal, KanagaVijayan Dhanabalan ... Subramanian Ramaswamy
    The first structure of a Neu5Ac bound Tripartite ATP-independent Periplasmic transporter (TRAP) reveals the presence of three ion binding sites.