Browse our Research Advances

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    1. Microbiology and Infectious Disease

    Peptidoglycan-tethered and free forms of the Braun lipoprotein are in dynamic equilibrium in Escherichia coli

    Yucheng Liang, Jean-Emmanuel Hugonnet ... Michel Arthur
    The Braun lipoprotein is tethered to peptidoglycan independently from the insertion of newly-synthesized peptidoglycan subunits into the expanding cell wall generating a dynamic equilibrium between free and bound protein forms.
    1. Chromosomes and Gene Expression

    An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression

    Chileleko Siachisumo, Sara Luzzi ... David J Elliott
    A family of RNA binding proteins that diverged 200 million years ago have parallel roles in protecting the transcriptomic integrity of ultra-long exons within their respective cell types.
    1. Cell Biology

    Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren’s disease

    Kai-Ting Huang, Larry E Wagner ... David I Yule
    In a mouse model of Sjogren's disease, mitochondrial function and Ca2+ signaling are disrupted resulting in altered coupling between Ca2+ release and Ca2+ activated Cl- channels and salivary gland hypofunction.
    1. Neuroscience

    Sex-dependent, lateralized engagement of anterior insular cortex inputs to the dorsolateral striatum in binge alcohol drinking

    David L Haggerty, Brady K Atwood
    Engagement of anterior insular cortex projections to the dorsolateral striatum underpins sex-differences in binge alcohol consumption behaviors.
    1. Neuroscience

    Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

    Benjamin R Kop, Yazan Shamli Oghli ... Lennart Verhagen
    Realizing the clinical and neuroscientific potential of transcranial ultrasonic stimulation (TUS) requires careful control of the peripheral auditory confounds that underlie previously reported online motor inhibitory effects.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals

    Lisa Baumgartner, Jonathan J Ipsaro ... Julius Brennecke
    Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.
    1. Neuroscience

    Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome

    Amin MD Shakhawat, Jacqueline G Foltz ... Jennifer L Raymond
    The capacity for new cerebellum-dependent learning is influenced by the recent history of neural activity in a mouse model of Fragile X syndrome, suggesting a role for metaplasticity.
    1. Structural Biology and Molecular Biophysics

    Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs

    Katarzyna Drożdżyk, Martina Peter, Raimund Dutzler
    Structural studies revealing the organization of assemblies consisting of CALHM2 and CALHM4 subunits provide insight into the mechanism of heteromerization of large pore channels.
    1. Medicine
    2. Neuroscience

    Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model

    Yunlu Xue, Yimin Zhou, Constance L Cepko
    Multiple alleles of Txnip, which can interact with several different proteins, including Hsp90AB1, were tested for their ability to prolong the survival of cone photoreceptors in diseases leading to blindness.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

    Natalia E Ketaren, Fred D Mast ... John D Aitchison
    High-affinity nanobodies targeting the SARS-CoV-2 spike protein demonstrate sustained effectiveness against current and emerging variants, offering a promising avenue for treatment.