A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
A broad and inclusive view of sex biases in hybrid dysfunction, irrespective of sexual system, expands the reach of Haldane's rule to help characterize the underlying forces and mechanisms responsible for predictable sex biases in evolutionary divergence and speciation.
The immune microenvironment has a pivotal role in hepatocellular carcinoma (HCC) progression and immune therapy resistance, and targeting this complex milieu holds great promise for improving therapeutic outcomes and patient prognoses in HCC management.
The 3R framework outlines three fundamental processes in motor learning and provides a novel perspective on understanding how we acquire, adapt, and retain complex motor skills.
Individuals with a history of adverse childhood experiences show blunted response to threat and reward irrespective of sample and paradigm characteristics and despite heterogeneity in adversity operationalization and assessment.
Phosphate and calcium from resorbing bone can find their way to the coronary circulation and contribute to atherosclerotic calcification of the blood vessels.
Advanced statistical and computational methods are reviewed and compared for integrating microbiome, host genomics, and metabolomics data, together with future research directions.
This quick reference guide for researchers addresses common misconceptions in the use of covariates in observational research and offers tips for preventing misstatements and mistakes.
