Review Articles

Review Articles are intended to bring readers up-to-date with research on important topics. Review Articles are commissioned by Senior Editors.

Latest articles

    1. Neuroscience

    Restoring vestibular function during natural self-motion: Progress and challenges

    Kantapon Pum Wiboonsaksakul, Olivia ME Leavitt Brown, Kathleen E Cullen
    Fully incorporating our current understanding of vestibular neurophysiology into prosthesis design and clinical application will be integral to the development of the next generation of vestibular prostheses.
    1. Genetics and Genomics

    Understanding genetic variants in context

    Nasa Sinnott-Armstrong, Stanley Fields ... Christine Queitsch
    Multiplexed assays of variant effect are an increasingly important tool in genetic research and including more context specificity in their design would aid interpretation and discovery.
    1. Neuroscience

    The BRAIN Initiative data-sharing ecosystem: Characteristics, challenges, benefits, and opportunities

    Sudhanvan Iyer, Kathryn Maxson Jones ... Mary A Majumder
    The BRAIN Initiative data-sharing ecosystem, consisting of seven data archives, faces interoperability and data stewardship challenges but nevertheless offers adaptability to the needs of particular research communities and raw material for network evolution.
    1. Neuroscience

    The gamma rhythm as a guardian of brain health

    Ana Maria Ichim, Harald Barzan ... Raul Cristian Muresan
    Fast oscillations (30-150Hz), generated by internal brain mechanisms may be essential for the maintenance of healthy brain function.
    1. Medicine
    2. Neuroscience

    Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research

    Alberto Granzotto, Bryce Vissel, Stefano L Sensi
    A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
    1. Structural Biology and Molecular Biophysics

    Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods

    Julia Belyaeva, Matthias Elgeti
    Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
    1. Evolutionary Biology

    Beyond Haldane’s rule: Sex-biased hybrid dysfunction for all modes of sex determination

    Asher D Cutter
    A broad and inclusive view of sex biases in hybrid dysfunction, irrespective of sexual system, expands the reach of Haldane's rule to help characterize the underlying forces and mechanisms responsible for predictable sex biases in evolutionary divergence and speciation.
    1. Cancer Biology

    Exploring the role of the immune microenvironment in hepatocellular carcinoma: Implications for immunotherapy and drug resistance

    Yumin Fu, Xinyu Guo ... Lianxin Liu
    The immune microenvironment has a pivotal role in hepatocellular carcinoma (HCC) progression and immune therapy resistance, and targeting this complex milieu holds great promise for improving therapeutic outcomes and patient prognoses in HCC management.
    1. Neuroscience

    Fundamental processes in sensorimotor learning: Reasoning, refinement, and retrieval

    Jonathan S Tsay, Hyosub E Kim ... Richard B Ivry
    The 3R framework outlines three fundamental processes in motor learning and provides a novel perspective on understanding how we acquire, adapt, and retain complex motor skills.
    1. Neuroscience

    How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

    Julia Ruge, Mana R Ehlers ... Tina B Lonsdorf
    Individuals with a history of adverse childhood experiences show blunted response to threat and reward irrespective of sample and paradigm characteristics and despite heterogeneity in adversity operationalization and assessment.