Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Computational and Systems Biology

   Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

   Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge

   Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
2. 1. Genetics and Genomics
   2. Cancer Biology

   Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

   Jiadong Zhou, Xiao Albert Zhou ... Jiadong Wang
3. 1. Cancer Biology

   The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

   Jie Fang, Shivendra Singh ... Jun Yang
4. 1. Computational and Systems Biology
   2. Cancer Biology

   Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation

   Yanbin Wang, Yuqi Wu ... Yanmei Zou
5. 1. Cancer Biology

   Formation of malignant, metastatic small cell lung cancers through overproduction of cMYC protein in TP53 and RB1 depleted pulmonary neuroendocrine cells derived from human embryonic stem cells

   Huanhuan Joyce Chen, Eric E Gardner ... Harold Varmus
6. 1. Immunology and Inflammation
   2. Cancer Biology

   Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers

   Sofia V Krasik, Ekaterina A Bryushkova ... Ekaterina O Serebrovskaya
7. 1. Cancer Biology

   Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma

   Yang Peng, Jing Yang ... Liang Weng
8. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

   Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury

   Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.
9. 1. Cancer Biology

   Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

   Yiwei Huang, Gujie Wu ... Cheng Zhan

   Chemotherapy remodels lung adenocarcinoma’s tumor microenvironment by driving metabolic reprogramming and shifting immune cell functions to modulate tumor progression and immune responses.
10. 1. Cancer Biology
    2. Cell Biology

    TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

    Maojin Tian, Le Yang ... Peiqing Zhao

    The TIPE/PKM2/HIF-1α signaling pathway plays a crucial role in enhancing cancer stem cell properties by facilitating glycolysis, thereby presenting a promising therapeutic target for melanoma intervention.