Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics

    A molecular proximity sensor based on an engineered, dual-component guide RNA

    Junhong Choi, Wei Chen ... Jay Shendure
    Revised
    Reviewed Preprint v2
    Updated
    1. Evolutionary Biology
    2. Genetics and Genomics

    Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic

    Michael James Chambers, Sophia B Scobell, Meru J Sadhu
    The innate immune protein PKR, which is inhibited by viral proteins that mimic its natural substrate, has access to a wide spectrum of inhibitor-evading mutations that maintain natural substrate binding.
    1. Genetics and Genomics
    2. Cancer Biology

    Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer

    Arkajyoti Bhattacharya, Thijs S Stutvoet ... Rudolf SN Fehrmann
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicing

    Karen Larissa Pereira de Castro, Jose M Abril ... W Samuel Fagg
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

    Thomas E Forman, Marcin P Sajek ... Katherine A Fantauzzo
    Revised
    Reviewed Preprint v2
    Updated
    1. Evolutionary Biology
    2. Genetics and Genomics

    Archaic introgression contributed to shape the adaptive modulation of angiogenesis and cardiovascular traits in human high-altitude populations from the Himalayas

    Giulia Ferraretti, Paolo Abondio ... Marco Sazzini
    A combination of composite-likelihood and gene network-based methods to investigate the impact of Denisovan introgression on the evolution of complex (i.e., polygenic) adaptive traits in high-altitude populations of Tibetan/Sherpa ancestry.
    1. Genetics and Genomics

    Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50’s ATPase activities and homologous recombination

    Sugith Badugu, Kshitiza M Dhyani ... Kalappa Muniyappa
    Revised
    Reviewed Preprint v2
    Updated
    1. Genetics and Genomics
    2. Neuroscience

    Characterizing the Spatial Distribution of Dendritic RNA at Single Molecule Resolution

    Jihoon Kim, Jean G Rosario ... Junhyong Kim
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

    Xiang Wang, Gan Shen ... Ying Shen
    DNAH3 is a novel pathogenic gene of male infertility and plays essential role in flagellar IDA assembly in humans and mice.
    1. Cancer Biology
    2. Genetics and Genomics

    Cancer: Predicting drug resistance

    Nicole S Arellano, Shannon E Elf
    A new approach helps examine the proportion of cancerous and healthy stem cells in patients with chronic myeloid leukemia and how this influences treatment outcomes.
    Version of Record
    Insight
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