Browse our latest Genetics and Genomics articles

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    1. Developmental Biology
    2. Genetics and Genomics

    Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

    Menglei Yang, Hafiz Muhammad Jafar Hussain ... Baolu Shi
    DNAH12 is essential for sperm flagellar development and male fertility in both humans and mice by interacting with dynein proteins DNAH1 and DNALI1.
    1. Genetics and Genomics

    Reported transgenerational responses to Pseudomonas aeruginosa in Caenorhabditis elegans are not robust

    Daniel Patrick Gainey, Andrey V Shubin, Craig P Hunter
    The failure to replicate key findings from an important report on transgenerational inheritance in Caenorhabditis elegans raises concerns about the robustness and ecological significance of the previously reported results.
    1. Genetics and Genomics

    Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function

    Omid Gholamalamdari, Tom van Schaik ... Andrew S Belmont
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Genetics and Genomics

    IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

    Mengjia Li, Hengchao Zhang ... Lixiang Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Loss of CTRP10 results in female obesity with preserved metabolic health

    Fangluo Chen, Dylan C Sarver ... G William Wong
    Mice lacking the secreted hormone, CTRP10, represent a unique female model of obesity with preserved metabolic health, highlighting sex-specific mechanisms that uncouple obesity from metabolic dysfunction.
    1. Genetics and Genomics
    2. Neuroscience

    Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus

    Akanksha Bafna, Gareth Banks ... Patrick M Nolan
    A multiomic study reveals the role of ZFHX3 transcription factor in daily timekeeping with a combination of transcription factor and histone ChIP-seq and time-resolved RNA-seq in the mammalian central clock.
    1. Genetics and Genomics

    MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics

    Naomi Martin, Paul Olsen ... Jack Waters
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Exceptional
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic legacy of aurochs hybridisation in ancient and modern Iberian cattle

    Torsten Günther, Jacob Chisausky ... Cristina Valdiosera
    After their introduction to the Iberian peninsula, domestic cattle hybridised with mostly male wild aurochs for millennia until human actions likely ended this process about 4000 years ago.
    1. Cell Biology
    2. Genetics and Genomics

    Cytosolic Carboxypeptidase 5 maintains mammalian ependymal multicilia to ensure proper homeostasis and functions of the brain

    Rubina Dad, Yujuan Wang ... Hui-Yuan Wu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete