Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics
    2. Evolutionary Biology

    The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

    Xiaopei Wang, Yongsen Ruan ... Haijun Wen
    Revised
    Reviewed Preprint v2
    Updated
    1. Cell Biology
    2. Genetics and Genomics

    Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress

    Showkat A Dar, Sulochan Malla ... Manolis Maragkakis
    Revised
    Reviewed Preprint v2
    Updated
    1. Genetics and Genomics
    2. Cancer Biology

    Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals

    Yaroslav Kainov, Fursham Hamid, Eugene V Makeyev
    Revised
    Reviewed Preprint v2
    Updated
    1. Developmental Biology
    2. Genetics and Genomics

    Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability

    Ignacy Czajewski, Bijayalaxmi Swain ... Daan MF van Aalten
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Functional characteristics and computational model of abundant hyperactive loci in the human genome

    Sanjarbek Hudaiberdiev, Ivan Ovcharenko
    Large-scale multi-omics analysis of genomic high-occupancy target regions in humans suggests involvement of large transcriptional condensates.
    1. Genetics and Genomics

    A molecular proximity sensor based on an engineered, dual-component guide RNA

    Junhong Choi, Wei Chen ... Jay Shendure
    Revised
    Reviewed Preprint v2
    Updated
    1. Evolutionary Biology
    2. Genetics and Genomics

    Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic

    Michael James Chambers, Sophia B Scobell, Meru J Sadhu
    The innate immune protein PKR, which is inhibited by viral proteins that mimic its natural substrate, has access to a wide spectrum of inhibitor-evading mutations that maintain natural substrate binding.
    1. Genetics and Genomics
    2. Cancer Biology

    Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer

    Arkajyoti Bhattacharya, Thijs S Stutvoet ... Rudolf SN Fehrmann
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicing

    Karen Larissa Pereira de Castro, Jose M Abril ... W Samuel Fagg
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

    Thomas E Forman, Marcin P Sajek ... Katherine A Fantauzzo
    Revised
    Reviewed Preprint v2
    Updated
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