Browse our Research Articles

Characterization of redox-active cysteines illuminates the understudied regulatory mechanisms of brain-selective kinases.

Experimental evolution of a duplicated gene increases mutational robustness relative to a single-copy gene but does not accelerate phenotypic evolution.

Knockout of CDK8/19, but not its inhibition, impairs spermatogenesis by reducing steroid production in Leydig cells.

Although methods to efficiently generate functional autonomic postganglionic neurons from human pluripotent stem cells largely mirror signaling cues during embryonic development, several in vivo signaling cues remain to be explored in vitro.

Behavioral and functional analyses revealed that UBR-1 deficiency in Caenorhabditis elegans disrupts glutamate signaling and confers ivermectin resistance.

Computational modelling suggests that the segmentation clock and the morphogenesis of the pre-somitic mesoderm exhibit developmental modularity, enabling the independent evolution of these processes and possibly contributing to the high evolvability of vertebrate segment number.

The peripherally restricted opioid receptor antagonist naloxone methiodide reverses fentanyl-induced respiratory depression without causing aversive behaviors that are observed after naloxone.

This enzymatic method enables highly specific and complete 1:1 protein conjugations with small molecules, solid supports, and other proteins, offering broad applicability across diverse biochemical and biotechnological applications.

Infralimbic inhibitory parvalbumin neurons play a counterintuitive role in supporting flexible behavior in the face of threat.

Crystallography, molecular dynamics simulations, and biochemical analyses of Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase (SBPase) from the microalga Chlamydomonas reinhardtii identify a redox module that controls oligomeric states for the activation of the enzyme.