Correction: Mycobacterium tuberculosis PhoP integrates stress response to intracellular survival by regulating cAMP level

1) Figure 1: There was an unintentional error in significance (p-value) when comparing cAMP secretion by WT-H37Rv and phoPR-KO shown in Figure 1B. The two star significance (**) is now changed to non-significant (ns). The change had no net effect on the reported values. The error was corrected in the associated Figure.

Corrected text in Figure 1 legend:

‘….in the corresponding culture filtrates (CF) (ns., non- significant)...’

Original text in Figure 1 legend is shown for reference:

‘….in the corresponding culture filtrates (CF) …..’

2) Figure 2: There were unintentional errors in significance (p-values) when comparing rv0891c expression between WT and phoPR-KO shown in Figure 2A and rv0805 expression in WT-H37Rv grown under pH 7.0 versus acidic pH (pH 4.5) shown in Figure 2B. In both Figures 2A and 2B, the two star (**) significance is now changed to one star (*) significance. These changes had no net effects on the reported values, but has a minor effect on statistics. The errors were corrected in the associated Figure.

Corrected text in Figure 2A legend:

‘….each with two technical repeats (*p<0.05; **p<0.01)…..’

Original text in Figure 2A legend is shown for reference:

‘….each with two technical repeats…..’

Corrected text in Figure 2B legend:

‘..as described in Materials and methods (*p<0.05)...’

Original text in Figure 2B legend is shown for reference:

‘..as described in Materials and methods (*p<0.01)...’

3) Figure 3: There have been errors in significance (p-values) while comparing cAMP levels of WT-Rv0805 and WT-Rv0805M in Figure 3C and phoP expression levels in WT and phoP-KD mutant in Figure 3D. Additionally, we spotted a minor error in the calculation of standard error of rv0805 expression [0.319 (corrected) from the original (0.967)] of phoP-KD mutant reported in Figure 3D. The associated figure, legend, and source data file are corrected. The changes are shown in bold. We have now included corrected source data file of Figure 3D.

Corrected text in Figure 3C legend:

‘….Significance in variation of cAMP levels was determined by paired Student’s t-test (*p<0.05; **p<0.01)……..’

Original text in Figure 3C legend is shown for reference:

‘….Significance in variation of cAMP levels was determined by paired Student’s t-test (**p<0.01)…..’

4) Figure 4: In the source data file of Figure 4A, the significance (p-values) was unintentionally omitted. In Figure 4B, there has been an error in the significance (p-value) between WT and the phoPR-KO mutant. Additionally, in Figures 4A and 4C one set of the triplicate datasets were used in plotting. The associated figure, legend and source data file are corrected. The changes are shown in bold. The three data sets were only present in the source data file, and did not affect Figure 4. We have now included corrected source data files of Figures 4A and 4C.

Corrected text in Figure 4B legend:

‘…., was determined by plotting fluorescence intensity (*p<0.05; **p<0.01; ***p<0.001)....’

Original text in Figure 4B legend is shown for reference:

‘…., was determined by plotting fluorescence intensity….’

5) Figure 3-figure supplement 1-source data 1: There were unintentional errors in significance (p-values) when comparing rv0805 expression between WT and WT-Rv0805 and between WT and WT-Rv0805M, respectively shown in Figure 3-figure supplement 1. In these cases, the three star (***) significance is now changed to two-star (**) significance and two-star significance (**) is now changed to one star (*) significance, respectively. These changes had no net effects on the reported values, but has a minor effect on statistics. The errors are corrected in the associated Figure.

Corrected text in Figure 3-figure supplement 1-source data 1 legend:

‘……as described in the Materials and methods (*p<0.05; **p<0.01)….....’

Original text in Figure 3-figure supplement 1-source data 1 legend is shown for reference:

‘……as described in the Materials and methods (**p≤0.01; ***p≤0.001)....’

The corrected Figure 1 is shown here:

The originally published Figure 1 is shown for reference:

The corrected Figure 2 is shown here:

The originally published Figure 2 is shown for reference:

The corrected Figure 3 is shown here:

The originally published Figure 3 is shown for reference:

The corrected Figure 4 is shown here:

The originally published Figure 4 is shown for reference:

The article has been corrected accordingly.