Science Forum: Challenges in validating candidate therapeutic targets in cancer

Calico Life Sciences, United States
Memorial Sloan Kettering Cancer Center, United States
Salk Institute for Biological Studies, United States

Feb 8, 2018

https://doi.org/10.7554/eLife.32402

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Table 1

Articles suggesting a link between MELK and human cancers.

The 33 articles listed in column 1 of this table suggest that MELK has a role in a variety of human cancers, which makes in a candidate therapeutic target for cancer drugs. Columns 2–5 indicate which articles reported certain kinds of evidence to make the link between MELK and cancer, column 6 indicates the studies that used a MELK inhibitor called OTS167 (which is currently undergoing clinical trials). However, three recent papers (Lin et al., 2017; Huang et al., 2017; Giuliano et al., 2018) suggest that MELK should not be considered as a candidate therapeutic target.

https://doi.org/10.7554/eLife.32402.002

	Articles reporting that MELK expression is up-regulated in various human cancers	Articles reporting an association between increased MELK expression and poor clinical prognosis	Articles reporting efficacy of MELK-targeted RNAi in cancer cell lines and/or xenograft tumor models	Articles reporting efficacy with small-molecule inhibitors of MELK in cancer cell lines and/or xenograft tumor models	Articles that made use of the MELK inhibitor OTS167 (also known as OTSSP167)
Gray et al. (2005)	x		x
Lin et al. (2007)	x		x
Marie et al. (2008)	x	x	x
Nakano et al. (2008)	x	x	x
Nakano et al. (2009)	x		x
Pickard et al. (2009)	x	x	x
Hebbard et al. (2010)			x
Choi and Ku (2011)			x
Chung et al. (2012)				x	x
Gu et al. (2013)	x	x	x
Kuner et al. (2013)	x	x
Minata et al. (2014)			x	x
Wang et al. (2014)	x		x	x	x
Du et al. (2014)	x	x	x
Alachkar et al. (2014)	x	x	x	x	x
Beke et al. (2015)				x
Li et al. (2016)	x	x	x	x	x
Inoue et al. (2016)	x		x	x	x
Chung et al. (2016)				x	x
Kato et al. (2016)				x	x
Touré et al., 2016			x	x
Wang et al. (2016)			x	x	x
Stefka et al. (2016)				x	x
Xia et al. (2016)	x	x	x
Speers et al., 2016	x	x	x	x	x
Hiwatashi et al., 2016	x	x
Kohler et al. (2017)	x	x		x	x
Simon et al. (2017)			x	x	x
Edupuganti et al. (2017)				x
Liu et al., 2017	x	x	x	x	x
Matsuda et al. (2017)			x
Bolomsky et al., 2017	x	x		x	x
Janostiak et al., 2017	x	x	x	x	x