Mutual interaction between visual homeostatic plasticity and sleep in adult humans
- University of Pisa, Italy
- École Normale Supérieure, UMR 8248 CNRS, France
Abstract
Sleep and plasticity are highly interrelated, as sleep slow oscillations and sleep spindles are associated with consolidation of Hebbian-based processes. However, in adult humans, visual cortical plasticity is mainly sustained by homeostatic mechanisms, for which the role of sleep is still largely unknown. Here we demonstrate that non-REM sleep stabilizes homeostatic plasticity of ocular dominance induced in adult humans by short-term monocular deprivation: the counter-intuitive and otherwise transient boost of the deprived eye was preserved at the morning awakening (>6 hours after deprivation). Subjects exhibiting a stronger boost of the deprived eye after sleep had increased sleep spindle density in frontopolar electrodes, suggesting the involvement of distributed processes. Crucially, the individual susceptibility to visual homeostatic plasticity soon after deprivation correlated with the changes in sleep slow oscillations and spindle power in occipital sites, consistent with a modulation in early occipital visual cortex.
Data availability
All data included in manuscript and supporting files
Article and author information
Author details
Maria Concetta Morrone
Funding
FP7 (338866 - Ecsplain)
- Maria Concetta Morrone
ERC (948366 - HOPLA)
- Claudia Lunghi
FP7 (832813 - GenPercept)
- Maria Concetta Morrone
MIUR and the French National Research Agency (ANR: AAPG 2019 JCJC,grant agreement ANR-19-CE28-0008,PlaStiC,and FrontCog grant ANR-17-EURE-0017)
- Claudia Lunghi
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Human subjects: All eligible volunteers signed an informed written consent. The study was approved by the Local Ethical Committee (Comitato Etico Pediatrico Regionale-Azienda Ospedaliero-Universitaria Meyer-Firenze), under the protocol "Plasticità del sistema visivo" (3/2011) and complied the tenets of the Declaration of Helsinki.
Copyright
© 2022, Menicucci et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Mutual interaction between visual homeostatic plasticity and sleep in adult humans
eLife 11:e70633.
https://doi.org/10.7554/eLife.70633
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