1. Neuroscience

Amygdala-cortical collaboration in reward learning and decision making

  1. Kate M Wassum  Is a corresponding author
  1. Department of Psychology, University of California, Los Angeles, United States
  2. Brain Research Institute, University of California, Los Angeles, United States
  3. Integrative Center for Learning and Memory, University of California, Los Angeles, United States
  4. Integrative Center for Addictive Disorders, University of California, Los Angeles, United States
https://doi.org/10.7554/eLife.80926
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  1. Kate M Wassum
(2022)
Amygdala-cortical collaboration in reward learning and decision making
eLife 11:e80926.
https://doi.org/10.7554/eLife.80926
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1 figure and 1 table

Figures

Figure 1
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Schematic of OFC-BLA circuit function.

Tables

Table 1
Key findings.
Outcome-specific learningOutcome-specific decision making
Sensitivity to devaluation
HubStimulus-OutcomeAction-outcomeIncentive valuePavlovian-to-instrumental transferPavlovian responsesInstrumental choiceIncentive value
BLANecessary Sias et al., 2021Necessary Corbit et al., 2013Necessary Malvaez et al., 2019; Parkes and Balleine, 2013; Wassum et al., 2009; Wassum et al., 2011Necessary Sias et al., 2021; Ostlund and Balleine, 2008; Corbit and Balleine, 2005; Hatfield et al., 1996; Blundell et al., 2001; Malvaez et al., 2015, Lichtenberg et al., 2021Necessary Sias et al., 2021; Hatfield et al., 1996; Johnson et al., 2009, Lichtenberg et al., 2021; Murray and Izquierdo, 2007; Málková et al., 1997; West et al., 2012Necessary Parkes and Balleine, 2013; Johnson et al., 2009; Murray and Izquierdo, 2007; Balleine et al., 2003; Coutureau et al., 2009Necessary Malvaez et al., 2019
lOFCNecessary Sias et al., 2021X38Necessary & Sufficient Malvaez et al., 2019; Baltz et al., 2018Necessary Ostlund and Balleine, 2007Necessary Ostlund and Balleine, 2007X40?
mOFC?Necessary Bradfield et al., 2015; Bradfield et al., 2018?Necessary Bradfield et al., 2015; Bradfield et al., 2018?Necessary & Sufficient Bradfield et al., 2015; Bradfield et al., 2018; Gourley et al., 2016Necessary & Sufficient Malvaez et al., 2019
Pathway
lOFCàBLANecessary Sias et al., 2021?Necessary & Sufficient Malvaez et al., 2019X20??X22
mOFCàBLA??X22Necessary Lichtenberg et al., 2021Necessary Lichtenberg et al., 2021X31Necessary & Sufficient Malvaez et al., 2019
BLAàlOFC???Necessary Sias et al., 2021Necessary Sias et al., 2021X20?
BLAàmOFC???X31Necessary Lichtenberg et al., 2021X31?

  1. Pavlovian-to-instrumental transfer refers to outcome-selective Pavlovian-to-instrumental transfer; X, not necessary; ?, no evidence known to the author currently in the literature.

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  1. Kate M Wassum
(2022)
Amygdala-cortical collaboration in reward learning and decision making
eLife 11:e80926.
https://doi.org/10.7554/eLife.80926