Special Issue: Reproductive health
Reproductive health issues affect hundreds of millions of people around the world every year, shaping everything from fertility and pregnancy outcomes to broader societal concerns, including demographic trends and healthcare disparities (ACOG, 2024). However, our knowledge and understanding of human reproduction and its associated disorders is incomplete. This is partly because research into reproductive health has historically been overlooked, with funding and attention disproportionately favoring other areas of medical research (Mercuri and Cox, 2022).
The decision to launch this special issue on reproductive health was motivated by several factors. One key driver was the recognition of how little we still know about the fundamental biology of reproduction and its disorders. Compounding this gap is the pressing need for robust, evidence-based insights to inform public debate and policy on topics such as abortion and IVF. Moreover, recent breakthroughs in research – such as organoid models, multi-omics techniques, and CRISPR-mediated gene editing – have opened up unprecedented opportunities to explore longstanding questions, catalyzing fresh momentum in the field.
The articles in the special issue span a wide array of topics, reflecting the diversity and complexity of reproductive health research. Several articles delve into the neuroendocrine regulation of reproduction, exploring how the brain and endocrine system orchestrate reproductive processes (Sáenz de Miera et al., 2024; Qiu et al., 2024; Hackwell et al., 2024). Others highlight epigenetic mechanisms, offering insights into how epigenetic changes influence fertility, pregnancy, and even the health of future generations (Verdikt et al., 2023; Cincotta et al., 2024; Lehle et al., 2024). Pregnancy and placental biology is another key theme, with articles addressing the mechanisms of normal gestation as well as the causes of complications such as preeclampsia and recurrent pregnancy loss (Liao et al., 2024; Wu et al., 2024). Further contributions investigate gamete biology and fertilization, illuminating the molecular and cellular events critical to sperm and egg formation (Wang et al., 2023; Muroňová et al., 2024; Granados-Aparici et al., 2024), and to sperm-egg interactions (Elofsson et al., 2024). Other articles offer new perspectives on the decline in fertility associated with aging (Huang et al., 2024; Amir et al., 2024).
Despite these advances, significant challenges remain. A persistent issue is the lack of comprehensive data on how lifestyle (such as dietary habits and levels of physical activity) and environmental factors (such as exposure to chemicals that disrupt the endocrine system) affect reproductive health. Equally concerning are disparities in reproductive health outcomes, which disproportionately impact marginalized communities (ACOG, 2024). Moreover, the biological mechanisms underlying common reproductive disorders, such as polycystic ovary syndrome, infertility, and recurrent pregnancy loss, remain poorly understood, hampering the development of effective treatments (NASEM, 2024). Outstanding open questions include: how do interactions between genetics, epigenetics and environmental factors shape reproductive health? And do assisted reproductive technologies have any long-term impacts on offspring health? Emerging organoid systems offer great promise, but their potential to model complex reproductive disorders effectively is still being explored (Kim et al., 2020).
By bringing together a wide range of innovative studies, we hope that this special issue will spark new conversations and collaborations among researchers, clinicians and policymakers. Moreover, in addition to deepening our understanding of reproductive biology, we hope that some of work reported in these articles will pave the way for advances in clinical medicine and more equitable healthcare practices worldwide. Finally, by highlighting the outstanding scientific challenges within reproductive health research, and the potential health benefits to billions of people around the world, we hope to encourage more researchers to work in the field and to convince governments and funding agencies of the need to increase their investment in this research for the good of both science and society.
References
-
Addressing social and structural determinants of health in the delivery of reproductive health careObstetrics & Gynecology 144:e113–e120.https://doi.org/10.1097/AOG.0000000000005721
-
Human organoids: Model systems for human biology and medicineNature Reviews Molecular Cell Biology 21:571–584.https://doi.org/10.1038/s41580-020-0259-3
-
BookA New Vision for Women’s Health ResearchWashington, DC: National Academies Press.https://doi.org/10.17226/28586
Article and author information
Author details
Publication history
Copyright
© 2025, Yan
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 362
- views
-
- 29
- downloads
-
- 0
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Further reading
-
- Developmental Biology
Apical constriction is a basic mechanism for epithelial morphogenesis, making columnar cells into wedge shape and bending a flat cell sheet. It has long been thought that an apically localized myosin generates a contractile force and drives the cell deformation. However, when we tested the increased apical surface contractility in a cellular Potts model simulation, the constriction increased pressure inside the cell and pushed its lateral surface outward, making the cells adopt a drop shape instead of the expected wedge shape. To keep the lateral surface straight, we considered an alternative model in which the cell shape was determined by cell membrane elasticity and endocytosis, and the increased pressure is balanced among the cells. The cellular Potts model simulation succeeded in reproducing the apical constriction, and it also suggested that a too strong apical surface tension might prevent the tissue invagination.
-
- Cancer Biology
- Developmental Biology
Missense ‘hotspot’ mutations localized in six p53 codons account for 20% of TP53 mutations in human cancers. Hotspot p53 mutants have lost the tumor suppressive functions of the wildtype protein, but whether and how they may gain additional functions promoting tumorigenesis remain controversial. Here, we generated Trp53Y217C, a mouse model of the human hotspot mutant TP53Y220C. DNA damage responses were lost in Trp53Y217C/Y217C (Trp53YC/YC) cells, and Trp53YC/YC fibroblasts exhibited increased chromosome instability compared to Trp53-/- cells. Furthermore, Trp53YC/YC male mice died earlier than Trp53-/- males, with more aggressive thymic lymphomas. This correlated with an increased expression of inflammation-related genes in Trp53YC/YC thymic cells compared to Trp53-/- cells. Surprisingly, we recovered only one Trp53YC/YC female for 22 Trp53YC/YC males at weaning, a skewed distribution explained by a high frequency of Trp53YC/YC female embryos with exencephaly and the death of most Trp53YC/YC female neonates. Strikingly, however, when we treated pregnant females with the anti-inflammatory drug supformin (LCC-12), we observed a fivefold increase in the proportion of viable Trp53YC/YC weaned females in their progeny. Together, these data suggest that the p53Y217C mutation not only abrogates wildtype p53 functions but also promotes inflammation, with oncogenic effects in males and teratogenic effects in females.