Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics
- Janelia Research Campus, Howard Hughes Medical Institute, United States
- University of Virginia, United States
- Columbia University, United States
Abstract
Animals employ diverse learning rules and synaptic plasticity dynamics to record temporal and statistical information about the world. However, the molecular mechanisms underlying this diversity are poorly understood. The anatomically defined compartments of the insect mushroom body function as parallel units of associative learning, with different learning rates, memory decay dynamics and flexibility (Aso & Rubin 2016). Here we show that nitric oxide (NO) acts as a neurotransmitter in a subset of dopaminergic neurons in Drosophila. NO's effects develop more slowly than those of dopamine and depend on soluble guanylate cyclase in postsynaptic Kenyon cells. NO acts antagonistically to dopamine; it shortens memory retention and facilitates the rapid updating of memories. The interplay of NO and dopamine enables memories stored in local domains along Kenyon cell axons to be specialized for predicting the value of odors based only on recent events. Our results provide key mechanistic insights into how diverse memory dynamics are established in parallel memory systems.
Data availability
Complete transcript data were deposited to NCBI Gene Expression Omnibus (accession number GSE139889).
Article and author information
Author details
Ashok Litwin-Kumar
Funding
Howard Hughes Medical Institute
- Yoshinori Aso
- Robert P Ray
- Xi Long
- Daniel Bushey
- Teri-TB Ngo
- Brandi Sharp
- Christina Christoforou
- Amy Hu
- Andrew L Lemire
- Paul Tillberg
- Gerald M Rubin
National Institutes of Health (R01 GM84128)
- Karol Cichewicz
- Jay Hirsh
Simons Foundation (Global Brain)
- Yoshinori Aso
- Ashok Litwin-Kumar
- Gerald M Rubin
Burroughs Wellcome Foundation
- Ashok Litwin-Kumar
Gatsby Charitable Foundation
- Ashok Litwin-Kumar
National Science Foundation (DBI-1707398)
- Ashok Litwin-Kumar
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Copyright
© 2019, Aso et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 7,999
- views
-
- 1,099
- downloads
-
- 121
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics
eLife 8:e49257.
https://doi.org/10.7554/eLife.49257
Further reading
-
- Neuroscience
By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.
