Meta-Research: COVID-19 medical papers have fewer women first authors than expected

  1. Jens Peter Andersen
  2. Mathias Wullum Nielsen
  3. Nicole L Simone
  4. Resa E Lewiss
  5. Reshma Jagsi  Is a corresponding author
  1. Aarhus University, Denmark
  2. University of Copenhagen, Denmark
  3. Sidney Kimmel Cancer Center at Thomas Jefferson University, United States
  4. Thomas Jefferson University, United States
  5. University of Michigan, United States

Abstract

The COVID-19 pandemic has resulted in school closures and distancing requirements that have disrupted both work and family life for many. Concerns exist that these disruptions caused by the pandemic may not have influenced men and women researchers equally. Many medical journals have published papers on the pandemic, which were generated by researchers facing the challenges of these disruptions. Here we report the results of an analysis that compared the gender distribution of authors on 1,893 medical papers related to the pandemic with that on papers published in the same journals in 2019, for papers with first authors and last authors from the United States. Using mixed-effects regression models, we estimated that the proportion of COVID-19 papers with a woman first author was 19% lower than that for papers published in the same journals in 2019, while our comparisons for last authors and overall proportion of women authors per paper were inconclusive. A closer examination suggested that women’s representation as first authors of COVID-19 research was particularly low for papers published in March and April 2020. Our findings are consistent with the idea that the research productivity of women, especially early-career women, has been affected more than the research productivity of men.

Data availability

The final dataset for the main analysis is available on OSF: https://osf.io/cpv2m/

The following data sets were generated

Article and author information

Author details

  1. Jens Peter Andersen

    Danish Centre for Studies on Research and Research Policy, Aarhus University, Aarhus, Denmark
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-2444-6210
  2. Mathias Wullum Nielsen

    Department of Sociology, University of Copenhagen, Copenhagen, Denmark
    Competing interests
    No competing interests declared.
  3. Nicole L Simone

    Department of Radiation Oncology, Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, United States
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-7662-7470
  4. Resa E Lewiss

    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, United States
    Competing interests
    Resa E Lewiss, Founder of TIME'S UP Healthcare, a non-profit initiative that advocates for safety and equity in healthcare; advisor for FeminEM.org, a website that supports the careers of women in medicine..
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-9512-4342
  5. Reshma Jagsi

    Department of Radiation Oncology and Center for Bioethics and Social Sciences in Medicine, University of Michigan, Ann Arbor, United States
    For correspondence
    rjagsi@med.umich.edu
    Competing interests
    Reshma Jagsi, Has stock options as compensation for her advisory board role in Equity Quotient, a company that evaluates culture in health care companies; has received personal fees from Amgen and Vizient and grants for unrelated work from the National Institutes of Health, the Doris Duke Foundation, the Greenwall Foundation, the Komen Foundation, and Blue Cross Blue Shield of Michigan for the Michigan Radiation Oncology Quality Consortium; has a contract to conduct an investigator-initiated study with Genentech; has served as an expert witness for Sherinian and Hasso and Dressman Benzinger LaVelle; uncompensated founding member of TIME'S UP Healthcare ; member of the Board of Directors of ASCO..
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-6562-1228

Funding

The authors declare that there was no funding for this work.

Copyright

© 2020, Andersen et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Metrics

  • 9,856
    views
  • 812
    downloads
  • 302
    citations

Views, downloads and citations are aggregated across all versions of this paper published by eLife.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Open citations (links to open the citations from this article in various online reference manager services)

Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)

  1. Jens Peter Andersen
  2. Mathias Wullum Nielsen
  3. Nicole L Simone
  4. Resa E Lewiss
  5. Reshma Jagsi
(2020)
Meta-Research: COVID-19 medical papers have fewer women first authors than expected
eLife 9:e58807.
https://doi.org/10.7554/eLife.58807
  1. Further reading

Further reading

  1. Edited by Peter A Rodgers
    Collection

    The study of science itself is a growing field of research.

    1. Immunology and Inflammation
    2. Medicine
    Ole Bæk, Tik Muk ... Duc Ninh Nguyen
    Research Article

    Preterm infants are susceptible to neonatal sepsis, a syndrome of pro-inflammatory activity, organ damage, and altered metabolism following infection. Given the unique metabolic challenges and poor glucose regulatory capacity of preterm infants, their glucose intake during infection may have a high impact on the degree of metabolism dysregulation and organ damage. Using a preterm pig model of neonatal sepsis, we previously showed that a drastic restriction in glucose supply during infection protects against sepsis via suppression of glycolysis-induced inflammation, but results in severe hypoglycemia. Now we explored clinically relevant options for reducing glucose intake to decrease sepsis risk, without causing hypoglycemia and further explore the involvement of the liver in these protective effects. We found that a reduced glucose regime during infection increased survival via reduced pro-inflammatory response, while maintaining normoglycemia. Mechanistically, this intervention enhanced hepatic oxidative phosphorylation and possibly gluconeogenesis, and dampened both circulating and hepatic inflammation. However, switching from a high to a reduced glucose supply after the debut of clinical symptoms did not prevent sepsis, suggesting metabolic conditions at the start of infection are key in driving the outcome. Finally, an early therapy with purified human inter-alpha inhibitor protein, a liver-derived anti-inflammatory protein, partially reversed the effects of low parenteral glucose provision, likely by inhibiting neutrophil functions that mediate pathogen clearance. Our findings suggest a clinically relevant regime of reduced glucose supply for infected preterm infants could prevent or delay the development of sepsis in vulnerable neonates.