Internal neural states influence the short-term effect of monocular deprivation in human adults.

  1. Yiya Chen
  2. Yige Gao
  3. Zhifen He
  4. Zhouyuan Sun
  5. Yu Mao
  6. Robert F Hess  Is a corresponding author
  7. Peng Zhang  Is a corresponding author
  8. Jiawei Zhou  Is a corresponding author
  1. Wenzhou Medical University, China
  2. Chinese Academy of Sciences, China
  3. McGill University, Canada

Abstract

The adult human visual system maintains the ability to be altered by sensory deprivation. What has not been considered is whether the internal neural states modulate visual sensitivity to short-term monocular deprivation. In this study we manipulated the internal neural state and reported changes in intrinsic neural oscillations with a patched eye open or closed. We investigated the influence of eye open/eye closure on the unpatched eye's contrast sensitivity and ocular dominance (OD) shifts induced by short-term monocular deprivation. The results demonstrate that internal neural states influence not only baseline contrast sensitivity but also the extent to which the adult visual system can undergo changes in ocular dominance.

Data availability

All data generated or analysed during this study are included in the manuscript and supporting file.

Article and author information

Author details

  1. Yiya Chen

    State Key Laboratory of Ophthalmology, Optometry and Visual Science, Wenzhou Medical University, Wenzhou, China
    Competing interests
    The authors declare that no competing interests exist.
  2. Yige Gao

    Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Competing interests
    The authors declare that no competing interests exist.
  3. Zhifen He

    State Key Laboratory of Ophthalmology, Optometry and Visual Science, Wenzhou Medical University, Wenzhou, China
    Competing interests
    The authors declare that no competing interests exist.
  4. Zhouyuan Sun

    Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Competing interests
    The authors declare that no competing interests exist.
  5. Yu Mao

    State Key Laboratory of Ophthalmology, Optometry and Visual Science, Wenzhou Medical University, Wenzhou, China
    Competing interests
    The authors declare that no competing interests exist.
  6. Robert F Hess

    Department of Ophthalmology and Visual Sciences, McGill University, Montreal, Canada
    For correspondence
    robert.hess@mcgill.ca
    Competing interests
    The authors declare that no competing interests exist.
  7. Peng Zhang

    Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    For correspondence
    zhangpeng@ibp.ac.cn
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-9603-8454
  8. Jiawei Zhou

    State Key Laboratory of Ophthalmology, Optometry and Visual Science, Wenzhou Medical University, Wenzhou, China
    For correspondence
    zhoujw@mail.eye.ac.cn
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-4220-344X

Funding

National Natural Science Foundation of China (31970975)

  • Jiawei Zhou

National Science and Technology Major Project (2022ZD0211900)

  • Peng Zhang

National Science and Technology Major Project (2021ZD0204200)

  • Peng Zhang

Natural Science Foundation for Distinguished Young scholars of zhejiang Province (LR22H120001)

  • Jiawei Zhou

Project of State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University (J02-20210203)

  • Jiawei Zhou

Canadian Institutes of Health Research (CCI-125686)

  • Robert F Hess

Natural Sciences and Engineering Research Council of Canada (228103)

  • Robert F Hess

ERA-NET Neuron (JTC2015)

  • Robert F Hess

National Natural Science Foundation of China (31871107)

  • Peng Zhang

National Natural Science Foundation of China (31930053)

  • Peng Zhang

Project of State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University (K03-20220102)

  • Peng Zhang

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Human subjects: This study complied with the Declaration of Helsinki and was approved by the Institutional Review Boards of Wenzhou Medical University. The methods were carried out in accordance with the approved guidelines under the protocol 'Adult amblyopia: binocular visual deficits and rehabilitation' version #1 dated 5/29/2019. All subjects were naive to the purpose of the study, and provided written informed consent which included consent to process and preserve the data and publish them in anonymous form.

Copyright

© 2023, Chen et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Yiya Chen
  2. Yige Gao
  3. Zhifen He
  4. Zhouyuan Sun
  5. Yu Mao
  6. Robert F Hess
  7. Peng Zhang
  8. Jiawei Zhou
(2023)
Internal neural states influence the short-term effect of monocular deprivation in human adults.
eLife 12:e83815.
https://doi.org/10.7554/eLife.83815

Share this article

https://doi.org/10.7554/eLife.83815

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