Rachel Sharninghausen, Jiwon Hwang ... Ryan D Baldridge
A generalizable approach to identify sequence features driving degradation from the endoplasmic reticulum (ER) provides useful tools for enabling ER-localized protein degradation.
The local PI(4,5)P2 nanodomain promotes the dimerization and activation of EGFR in the plasma membrane, whereas activated EGFR dissolves the nanodomain structure of PI(4,5)P2 through PLCγ.