A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology
- CNRS Sorbonne-Université, France
- Sorbonne Université, INSERM, France
Abstract
Spatiotemporal mechanisms generating neural diversity are fundamental for understanding neural processes. Here, we investigated how neural diversity arises from neurons coming from identical progenitors. In the dorsal thorax of Drosophila, rows of mechanosensory organs originate from the division of sensory organ progenitor (SOPs). We show that in each row of the notum, an anteromedial located central SOP divides first, then neighbouring SOPs divide, and so on. This centrifugal wave of mitoses depends on cell-cell inhibitory interactions mediated by SOP cytoplasmic protrusions and Scabrous, a secreted protein interacting with the Delta/Notch complex. Furthermore, when this mitotic wave was reduced, axonal growth was more synchronous, axonal terminals had a complex branching pattern and fly behaviour was impaired. We show that the temporal order of progenitor divisions influences the birth order of sensory neurons, axon branching and impact on grooming behaviour. These data support the idea that developmental timing controls axon wiring neural diversity.
Data availability
All data generated or analysed during this study are included in the manuscript and supporting files.
Article and author information
Author details
Sophie Louvet-Vallée
Funding
Funding was provided by recurrent subsides from the Centre National de la Recherche Scientifique and the Sorbonne University. No external funding was receives for this work.
Copyright
© 2022, Lacoste et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology
eLife 11:e75746.
https://doi.org/10.7554/eLife.75746
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