Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry
- German Center for Neurodegenerative Diseases, Germany
- Leibniz Institute for Neurobiology, Germany
- Otto-von-Guericke University Magdeburg, Germany
Abstract
Scene and object information reach the entorhinal-hippocampal circuitry in partly segregated cortical processing streams. Converging evidence suggests that such information-specific streams organize the cortical - entorhinal interaction and the circuitry's inner communication along the transversal axis of hippocampal subiculum and CA1. Here, we leveraged ultra-high field functional imaging and advance Maass, Berron et al. (2015) who report two functional routes segregating the entorhinal cortex (EC) and the subiculum. We identify entorhinal subregions based on preferential functional connectivity with perirhinal Area 35 and 36, parahippocampal and retrosplenial cortical sources (referred to as ECArea35-based, ECArea36-based, ECPHC-based, ECRSC-based, respectively). Our data show specific scene processing in the functionally connected ECPHC-based and distal subiculum. Another route, that functionally connects the ECArea35-based and a newly identified ECRSC-based with the subiculum/CA1 border, however, shows no selectivity between object and scene conditions. Our results are consistent with transversal information-specific pathways in the human entorhinal-hippocampal circuitry, with anatomically organized convergence of cortical processing streams and a unique route for scene information. Our study thus further characterizes the functional organization of this circuitry and its information-specific role in memory function.
Data availability
Source data that contain numerical data used to generate Figure 2, Figure 3, Figure 4, Appendix 1 Figure 2, Appendix 1 Figure 3, Appendix 1 Figure 4, Appendix 5 Figure 1 as well as group-level statistical maps (referred to as Source Code 1-16) that underlie Figure 1, Figure 2, Appendix 1 Figure 1, Appendix 1 Figure 2, Appendix 3 Figure 1, Appendix 3 Figure 2 and Appendix 4 Figure 1 have been provided under:Open Science Framework. ID 9v3qp. https://osf.io/9v3qp
-
Source Data from Functional Connectivity and Information Processing in the Entorhinal-Hippocampal CircuitryOpen Science Framework. ID 9v3qp.
Article and author information
Author details
Magdalena M Sauvage
Funding
Horizon 2020 Research and Innovation Programme (785907 (HBP SGA2) and 945539 (HBP SGA3))
- Emrah Düzel
Deutsche Forschungsgemeinschaft (Project-ID 42589994)
- Magdalena M Sauvage
- Emrah Düzel
HORIZON EUROPE Marie Sklodowska-Curie Actions (843074)
- David Berron
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Human subjects: Informed consent and consent to publish was obtained from human participants.The study received approval by the ethics committee of Otto-von-Guericke University, Magdeburg (Germany) under reference number 128/14.
Copyright
© 2022, Grande et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 1,177
- views
-
- 322
- downloads
-
- 18
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry
eLife 11:e76479.
https://doi.org/10.7554/eLife.76479
Further reading
-
- Neuroscience
We used diffusion MRI and x-ray synchrotron imaging on monkey and mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. We compared the structure in the corpus callosum and crossing fibre regions and investigated the differences in cuprizone-induced demyelination in mouse brains versus healthy controls. Our findings revealed common principles of fibre organisation that apply despite the varying patterns observed across species; small axonal fasciculi and major bundles formed laminar structures with varying angles, according to the characteristics of major pathways. Fasciculi exhibited non-straight paths around obstacles like blood vessels, comparable across the samples of varying fibre complexity and demyelination. Quantifications of fibre orientation distributions were consistent across anatomical length scales and modalities, whereas tissue anisotropy had a more complex relationship, both dependent on the field-of-view. Our study emphasises the need to balance field-of-view and voxel size when characterising white matter features across length scales.
-
- Biochemistry and Chemical Biology
- Neuroscience
The buildup of knot-like RNA structures in brain cells may be the key to understanding how uncontrolled protein aggregation drives Alzheimer’s disease.
