Browse our Research Articles

Page 4 of 1,370
    1. Physics of Living Systems

    Cell cycle and age-related modulations of mouse chromosome stiffness

    Ning Liu, Wenan Qiang ... Huanyu Qiao
    Mammalian condensed chromosomes exhibit diverse structural properties, as reflected in their varying stiffness across different cell stages and with aging.
    1. Evolutionary Biology

    Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation

    Wei-Yun Lai, Sheng-Kai Hsu ... Christian Schlötterer
    Evolved gene expression changes in Drosophila simulans uncovered the interplay between parallel evolution, polymorphism, and pleiotropy and indicated that both direct and indirect effects of pleiotropy contribute to parallel evolution.
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    1. Evolutionary Biology

    Developing a crop- wild-reservoir pathogen system to understand pathogen evolution and emergence

    Mark McMullan, Lawrence Percival-Alwyn ... Neil Hall
    Evidence for those pathogen genes selected specifically for success on crops.
    1. Neuroscience

    Dynamic gamma modulation of hippocampal place cells predominates development of theta sequences

    Ning Wang, Yimeng Wang ... Dong Ming
    A subset of hippocampal place cells, which is phase-locked to fast gamma rhythms, compressively encodes information at precessing slow gamma phases and therefore predominates to theta sequence development.
    1. Neuroscience

    Diverging roles of TRPV1 and TRPM2 in warm-temperature detection

    Muad Y Abd El Hay, Gretel B Kamm ... Jan Siemens
    Different aspects of thermal stimuli, such as speed and intensity, are detected by distinct TRP channel-based mechanisms, with TRPV1 and TRPM2 playing unique roles in warmth perception and thermal decision-making.
    1. Neuroscience

    Mechanisms that regulate the C1-C2B mutual inhibition control functional switch of UNC-13

    Haowen Liu, Lei Li ... Zhitao Hu
    A novel mechanistic mechanism in UNC-13/Munc13 regulates synaptic neurotransmitter release at the Caenorhabditis elegans neuromuscular junction.
    1. Cancer Biology

    Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

    Weijie Wu, Miao Yu ... Hongquan Zhang
    Tumor-suppressive protein FRMD8 inhibits breast cancer progression by regulating the level of ERα and has the possibility to be a potential target for overcoming tamoxifen treatment resistance.
    1. Cell Biology

    Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages

    Tomoharu Kanie, Roy Ng ... Peter K Jackson
    Neuronal Calcium Sensor-1 (NCS1) is a protein that captures the preciliary vesicle in the early step of the cilium formation.
    1. Cell Biology

    A hierarchical pathway for assembly of the distal appendages that organize primary cilia

    Tomoharu Kanie, Beibei Liu ... Peter K Jackson
    Comprehensive analyses of localization, hierarchy, and function of the proteins located at the distal appendages of the centriole.
    1. Cancer Biology
    2. Physics of Living Systems

    Mechanistic insight for T-cell exclusion by cancer-associated fibroblasts in human lung cancer

    Joseph Ackermann, Chiara Bernard ... Martine D Ben Amar
    The crosstalk between cancerous lesions and the immune system in the lungs demonstrates the complex role of fibroblasts.