It was revealed that phosphorylation of the DNA repair enzyme PNKP at threonine 118 by CDK is required for DNA replication through the gap filling of Okazaki fragments.
Oxidized LDL synergizes with angiotensin II to amplify Gq signaling via the AT1-LOX1 receptor complex, revealing a novel mechanism driving renal dysfunction in hypertension and dyslipidemia.