Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production

    Conan J O O’Brien, Giorgio Ratti ... Ana I Domingos
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Conserved biophysical compatibility among the highly variable germline-encoded regions shapes TCR-MHC interactions

    Christopher T Boughter, Martin Meier-Schellersheim
    A comprehensive computational study of germline-encoded T cell receptor CDR loops and MHC alpha-helices finds limited evidence for evolutionary conserved interactions, and instead suggests broad biophysical compatibility guides the interactions between the two proteins.
    1. Immunology and Inflammation

    Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

    Kentarou Waki, Hideki Tani ... Nobuyuki Kurosawa
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

    Jaemoon Koh, Yeon Duk Woo ... Doo Hyun Chung
    The development and functionalities of invariant natural-killer T cells are dependent upon their cell-intrinsic ACC1-mediated de novo fatty acid synthesis, which greatly affect outcomes of allergic asthma.
    1. Immunology and Inflammation

    CCR1 mediates Müller cell activation and photoreceptor cell death in macular and retinal degeneration

    Sarah Elbaz-Hayoun, Batya Rinsky ... Itay Chowers
    A novel therapy for a common blinding retinal disease uses an innovative CCR1 blocking-based strategy.
    1. Immunology and Inflammation

    Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

    Eva Morgun, Jennifer Zhu ... Chyung-Ru Wang
    The bicontinuous nanospheres platform enables dual encapsulation and in vivo activation of lipid and protein antigen-specific T cells, resulting in enduring lipid depots for sustained immune responses.
    1. Immunology and Inflammation

    H2-O deficiency promotes regulatory T cell differentiation and CD4 hyperactivity

    Robin A. Welsh, Nianbin Song ... Scheherazade Sadegh-Nasseri
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Immunology and Inflammation

    ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB mediated inflammatory reactions in humans and mice

    Chong Chen, Qian Liu ... Xinting Liu
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation

    Jian Cui, Hua Li ... Congqing Wu
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

    Sabelo Hadebe, Anca Flavia Savulescu ... Frank Brombacher
    Not revised
    Reviewed Preprint v1
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