Extremely early antiretroviral therapy during HIV-1 subtype C infection leads to faster decline in genome-intact viruses, reduced genetic complexity, and immune escape, and may enhance reservoir clearance with additional interventional strategies.
Benita Martin-Castaño, Patricia Diez-Echave ... Julio Galvez
Biomarkers of COVID-19 severity identified in nasopharyngeal and faecal microbiota could improve prognostic accuracy and treatment strategies for severe cases.
Vivian C Salgueiro-Toledo, Jorge Bertol ... Rafael Prados-Rosales
Genetic, ultrastructural, multi-omics, and biochemical tools reveal VirR as a central scaffold in Mycobacterium tuberculosis cell envelope remodelling, critical for extracellular vesicle production.
The observation that an additional vaccine dose provides protection against Omicron variant reinfection in previously vaccinated and infected individuals will help guide future COVID-19 vaccination policies in China and globally.
Manuela C Aguirre-Botero, Olga Pacios ... Rogerio Amino
A late-neutralizing monoclonal antibody targeting the major surface antigen of plasmodial sporozoites impairs the fitness of intracellular parasites, offering mechanistic insights to guide the development of potent anti-malaria antibodies.
Julia A Hotinger, Ian W Campbell ... Matthew K Waldor
Microbial lineage tracing during murine systemic infection with Salmonella uncovered the bottlenecks that restrict colonization and the hidden routes of interorgan dissemination that drive heterogeneity in infection outcomes.
