Browse our latest Stem Cells and Regenerative Medicine articles

Page 10 of 53
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation

    Tao Zhang, Liyang Wan ... Hongbin Lu
    Single-cell RNA sequencing to delineate the comprehensive postnatal RC enthesis growth from as early as postnatal day 1 to postnatal day 56.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland

    Valeria Scagliotti, Maria Lillina Vignola ... Marika Charalambous
    Pituitary gland size and stem cell number is modulated during early life in the mouse by the imprinted gene Dlk1, which acts in multiple developmental compartments in a dosage-sensitive manner.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

    Damien Detraux, Marino Caruso ... Patricia Renard
    Accumulation of succinate during the in vitro modeling of embryonic stem cell state transition critically regulate cell fate.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5

    Dong Wang, Tiemei Zheng ... Bin Yu
    Inhibiting RNA N6-methyladenosine demethylase ALKBH5 promoted axonal regeneration of dorsal root ganglion neurons by regulating stability of Lpin2 mRNA and enhanced the survival and axonal regeneration of retinal ganglion cells.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Rubella virus tropism and single-cell responses in human primary tissue and microglia-containing organoids

    Galina Popova, Hanna Retallack ... Tomasz Nowakowski
    Combination of primary brain culture and single-cell RNA sequencing in brain organoids identifies microglia as the main target of rubella virus infection.
    Version of Record
    Short Report
    • Important
    • Compelling
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation

    Francisco X Galdos, Carissa Lee ... Sean M Wu
    TBX5 lineage tracing and high resolution single cell transcriptomics uncover the predominance of first heart field development during human-induced pluripotent stem cell cardiac differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cardiac Development: Tracing the history of a heart

    Brian Spurlock, Li Qian
    Newly developed tools will help researchers understand how the human heart develops and build better models to study and treat congenital heart disease.
    Version of Record
    Insight
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Low-level repressive histone marks fine-tune gene transcription in neural stem cells

    Arjun Rajan, Lucas Anhezini ... Cheng-Yu Lee
    Stem-cell-specific transcriptional repressors fine-tune levels of stemness gene transcripts in asymmetrically dividing neural stem cells by depositing low levels of repressive histone marks at these loci allowing progeny to rapidly initiate differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance

    Virginia Folgado-Marco, Kristina Ames ... Nicholas E Baker
    The homozygous and heterozygous phenotypes of mouse Rps12 deletion are described, highlighting pancytopenia reflecting roles in hematopoiesis and erythropoiesis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cell-free DNA as a potential biomarker of differentiation and toxicity in cardiac organoids

    Brian Silver, Kevin Gerrish, Erik Tokar
    Cardiac organoids have potential as a tool used for identifying cell-free DNA as biomarkers for toxicity and severity of exposure outcomes.