Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice

    Wenbin An, Maria Feola ... Yelena Ginzburg
    Dysregulated erythroblast-specific iron trafficking and regulation of iron metabolism provides evidence of a novel potential therapeutic target to reverse ineffective erythropoiesis in MDS.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells

    Roxane Verdikt, Abigail A Armstrong ... Patrick Allard
    Exposure of embryonic stem cells to physiological concentrations of Δ9-THC remodels cellular metabolism across differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem Cells: Investigating the impact of cannabis

    Merrick Pierson Smela
    The psychoactive component of cannabis, ∆9-THC, affects cell growth and metabolism in early embryonic cell types in mice.
    Version of Record
    Insight
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy

    Yurika Ito, Mari Yamagata ... Takahiko Sato
    The maintenance of proper mitochondrial-associated endoplasmic reticulum membranes is crucial for preventing skeletal muscle atrophy to interact with the Notch signaling pathway.
    1. Stem Cells and Regenerative Medicine

    Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors

    Lampros Mavrommatis, Hyun-Woo Jeong ... Holm Zaehres
    Skeletal muscle organoids differentiated from human pluripotent stem cells offer a system for investigating myogenesis and satellite cell development with translational potential for muscular dystrophy modeling and therapy development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells

    Lars N Royall, Diana Machado ... Annina Denoth-Lippuner
    Genetic birthdating in forebrain organoids shows asymmetric inheritance of centrosomes in human neural progenitor cells, required for proper human neurogenesis.
    1. Stem Cells and Regenerative Medicine

    An in vitro model for vitamin A transport across the human blood–brain barrier

    Chandler B Est, Regina M Murphy
    A human stem cell-derived in vitro model provided novel insights into the mechanisms of retinoid accumulation in, and permeation across, the blood–brain barrier.
    1. Stem Cells and Regenerative Medicine

    Germ Cells: From stem cell to egg cell

    Noor M Kotb, Prashanth Rangan
    Experiments on female fruit flies reveal more about the molecular mechanisms involved as germline stem cells transition to become egg cells.
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    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Multiomics analyses reveal dynamic bioenergetic pathways and functional remodeling of the heart during intermittent fasting

    Thiruma V Arumugam, Asfa Alli-Shaik ... Jayantha Gunaratne
    Intermittent fasting orchestrates molecular shifts, yielding cardiovascular improvements, revealing novel cardioprotective mechanisms, and suggesting innovative pharmacological strategies for cardiovascular disease prevention and treatment.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation

    Tao Zhang, Liyang Wan ... Hongbin Lu
    Single-cell RNA sequencing to delineate the comprehensive postnatal RC enthesis growth from as early as postnatal day 1 to postnatal day 56.