Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver

    Abby Sarkar, Yinhua Jin ... Roel Nusse
    Hepatocytes proliferate to maintain a constant liver-to-body mass ratio during intermittent fasting.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures

    Nazir M Khan, Martha Elena Diaz-Hernandez ... Hicham Drissi
    The iPSCs derived from OA cartilage showed memory of disease which affect its chondrogenic potential and regulation at epigenetic and metabolic level may be used to control the regenerative potential of these iPSCs.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Mir155 regulates osteogenesis and bone mass phenotype via targeting S1pr1 gene

    Zhichao Zheng, Lihong Wu ... Janak L Pathak
    Mir155 showed a catabolic effect on osteogenesis and bone mass phenotype via interaction with the S1pr1 gene, suggesting inhibition of Mir155 as a potential approach to bone regeneration and bone defect healing.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Germline/soma distinction in Drosophila embryos requires regulators of zygotic genome activation

    Megan M Colonnetta, Paul Schedl, Girish Deshpande
    Components of zygotic genome activation, Zelda and CLAMP, contribute to the proper specification of primordial germ cells in Drosophila embryos.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

    Amrita A Iyer, Ishwar Hosamani ... Andrew K Groves
    Cells of the mammalian cochlea can be reprogrammed to produce mechanosensory hair cells, but epigenetic changes in the cochlea make this process less efficient with age.
    1. Stem Cells and Regenerative Medicine

    High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy

    Kevin Schilling, Yuankun Zhai ... Xinping Zhang
    High-resolution multiphoton microscopy reveals coupling of blood vessel subtype with expanding osteoblasts at the bone regeneration interface, further highlighting the heterogeneity of oxygen microenvironment and its impact on cellular energy metabolism of bone and vessel forming cells.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

    Fu-Qing Jiang, Kun Liu ... Xu-Feng Qi
    Mettl3 post-transcriptionally reduces Fgf16 mRNA levels through an m6A-Ythdf2-dependen pathway, thereby controlling cardiomyocyte proliferation and heart regeneration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

    Wenbo Liu, Xukun Lu ... Jianqiao Liu
    SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Vinculin recruitment to α-catenin halts the differentiation and maturation of enterocyte progenitors to maintain homeostasis of the Drosophila intestine

    Jerome Bohere, Buffy L Eldridge-Thomas, Golnar Kolahgar
    A subset of intestinal precursor cells is able to sense mechanical forces at cell–cell junctions to control the production of specialised cells.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Highly efficient generation of isogenic pluripotent stem cell models using prime editing

    Hanqin Li, Oriol Busquets ... Frank Soldner
    A highly efficient platform to engineer designer mutations in human stem cells using RNA-based delivery of prime editing components.