Predictive pharmacology based on behavioural fingerprinting can identify druggable pathways that are altered or renormalized in zebrafish larvae that harbor mutations in early and late-onset Alzheimer's disease risk genes.
Gabriella O Estevam, Edmond Linossi ... James S Fraser
A deep mutational scan of MET kinase domain variants reveals resistance and sensitizing mutations for 11 inhibitors, providing a mutation-specific reference for precision therapies and drug development.
Christopher Bell, Lukas Kilo ... Stefanie Ryglewski
Mutually exclusive splicing of two exon pairs of the only Drosophila Cav2 homolog cacophony mediates functional diversity of Cav2 channels in Drosophila.
Manuela C Aguirre-Botero, Olga Pacios ... Rogerio Amino
A late-neutralizing monoclonal antibody targeting the major surface antigen of plasmodial sporozoites impairs the fitness of intracellular parasites, offering mechanistic insights to guide the development of potent anti-malaria antibodies.
Kaspar E Vogt, Ashwinikumar Kulkarni ... Robert W Greene
Sleep's role to down-scale glutamate, excitatory, frontal cortical synapses is extended to include an up-scaling of metaplastic LTP potential, in recovery from prolonged waking induced saturation of this LTP potential.
Julia A Hotinger, Ian W Campbell ... Matthew K Waldor
Microbial lineage tracing during murine systemic infection with Salmonella uncovered the bottlenecks that restrict colonization and the hidden routes of interorgan dissemination that drive heterogeneity in infection outcomes.
Adaptation of domesticated maize and its wild relative teosinte has been facilitated by the geographically widespread exchange of beneficial alleles between them.
A data-driven exploration of amygdala microstructure captures this region's subnuclear structure and dissociates its cortical functional connectivity profiles.
