Pre-hematopoietic stem cells emerge from the aortic floor according to two radically different morphodynamics whose biomechanics rely on controlling apicobasal polarity in hemogenic precursors, which may impact on their fate.
Corey D Holman, Alexander P Sakers ... Patrick Seale
Single-cell expression profiling and genetic lineage analysis show that aging impairs adipocyte differentiation from precursor cells and blocks the thermogenic activation of adipocytes during cold exposure.
FMNL2 associates with Formin2 and Arp2/3 complex for actin assembly, which further regulates spindle migration and INF2/Cofilin-related organelle dynamics during mammalian oocyte maturation.
