Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
Soluble Fas ligand interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as death receptor 5, exacerbating arthritis in a Fas-independent manner.
A new disposition mechanism for glucuronides, where liver serves as recycle organ and intestine serves as metabolism organ, is established to better explain the disposition of phenolics in vivo.
The TRPM4 ion channel has been identified as an important component in the causation of mechanical pressure overload-induced pathological left ventricular hypertrophy, which is a powerful predictor of cardiovascular mortality.
Dinavahi VPS Murty, Keerthana Manikandan ... Supratim Ray
Visual narrow-band gamma rhythms are reduced in mild cognitive impairment and Alzheimer’s disease, confirming previous rodent research and forming crucial first steps for development of EEG-based biomarkers for humans.
Cheng-Chia Tang, Christian D Castro Andrade ... Marc N Wein
Simultaneous inhibition of two distinct kinase targets stimulates bone formation without concurrently increasing bone resorption, therefore representing a promising new treatment strategy for osteoporosis.
Chitinase 3-like-1 promotes Kupffer cells to recruit platelets, thereby contributing to liver injury, and serves as a therapeutic target in acetaminophen-induced liver injury.
