Photonic hyperthermia of malignant peripheral nerve sheath tumors at the third near-infrared biowindow
- Shanghai Ninth People's Hospital, China
- Shanghai Universityy, China
- Shanghai Institute of Ceramics, China
- Shanghai University, China
Abstract
Malignant peripheral nerve sheath tumors (MPNSTs), as typical aggressive sarcomas, typically carry a dismal prognosis. Given the insensitivity of these tumors to traditional chemotherapy and the absence of effective targeted drugs, new therapeutic strategies for efficient MPNSTs treatment are urgently needed. Recently, photothermal therapy (PTT) has demonstrated significant potential in cancer theranostics due to its minimally invasive nature and excellent therapeutic outcomes. However, the passive utilization of photothermal agents (PTAs) with poor target specificity and biocompatibility substantially hinders the clinical translation and application of this method. A unique near-infrared laser at the third biowindow (NIR-III) was utilized for photonic hyperthermia treatment of MPNSTs without PTAs. The superficial locations and relatively high collagen content of MPNSTs ensure the efficiency of photothermal tumor ablation and make the NIR-III laser a suitable therapeutic option that has potential for use in clinical applications. Using human MPNST cell line and xenograft models, it can be found that although the NIR-III photothermal treatment efficiency varied among individuals, which was possibly influenced by different endoplasmic reticulum stress responses (ERSRs), the expected antineoplastic effect was ultimately achieved after adjustment of the power density and radiation duration. The present study provides an intriguing noninvasive therapy for MPNSTs that accelerates the clinical translation of PTT while avoiding the biocompatibility issues arising from PTAs.
Data availability
The generic database-'Dryad' has been chosen.The unique identifier: doi:10.5061/dryad.3bk3j9km7All data generated or analysed during this study are included in the manuscript and supporting file.
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Photonic hyperthermia of malignant peripheral nerve sheath tumors at the third near-infrared biowindowDryad Digital Repository, doi:10.5061/dryad.3bk3j9km7.
Article and author information
Author details
Funding
National Natural Science Foundation of China (82102344)
- Zhichao Wang
National Natural Science Foundation of China (82172228)
- Qingfeng Li
Shanghai Rising star Program (20QA1405600)
- Zhichao Wang
Natural Science Foundation of Shanghai (22ZR1422300)
- Zhichao Wang
Science and Technology Commission of Shanghai Municipality (19JC1413)
- Qingfeng Li
Shanghai Education Development Foundation (19CG18)
- Zhichao Wang
Shanghai Municipal Key Clinical Specialty (shslczdzk00901)
- Qingfeng Li
Innovative research team of high-level local universities in Shanghai (SSMU-ZDCX20180700)
- Qingfeng Li
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All animals received humane care in compliance with the guidelines outlined in the Guide for the Care and Use of Laboratory Animals. All procedures were performed in accordance with the guidelines approved by the Shanghai Medical Experimental Animal Care Commission (IACUC: 2019-0008).
Human subjects: The use of photos and magnetic resonance images of MPNST patients was approved by the Ethics Committee of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (Reference number: SH9H-2019-T163-2). Informed consent and consent to publish were obtained from patients under institutional review board protocols.
Copyright
© 2022, Gu et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Photonic hyperthermia of malignant peripheral nerve sheath tumors at the third near-infrared biowindow
eLife 11:e75473.
https://doi.org/10.7554/eLife.75473
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