Herschel S Dhekne, Francesca Tonelli ... Suzanne R Pfeffer
Activating mutations in the leucine-rich repeat kinase 2 cause Parkinson’s disease, and an unbiased genome-wide screen revealed an unexpected, specific role for Rab12 in activating this kinase directly for Rab GTPase phosphorylation.
Bronwyn A Lucas, Benjamin A Himes, Nikolaus Grigorieff
2D template matching enables a streamlined single-particle cryogenic electron microscopy workflow that can be used to discover new high-resolution structural features in molecules and complexes, such as bound ligands and drugs.
Open science and consensus antibody validation protocols can identify high-quality, renewable antibodies for the ~50% of the human proteome currently covered, enabling robust and reproducible biomedical research.
Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.
Neural network modeling shows that hierarchical application of the simple computational principle of predicting future sensory input from its past can capture features of visual motion processing from the retina to the visual cortex.
Interactions between cortical and subcortical circuits in the mammalian brain flexibly control the flow of information streams that drive decisions by shifting the balance of power both within and between action representations.
Franziska Grathwol, Christian Roos ... Gisela H Kopp
The first sequenced mitogenome of a mummified non-human primate connects an Egyptian baboon dated to ca. 800–540 BCE to modern baboon populations in Eritrea, Ethiopia, and eastern Sudan, providing evidence for Egyptian–Adulite trade centuries earlier than current archaeological evidence.
Elliott L Paine, Jack J Skalicky ... Wesley I Sundquist
Biochemical, structural, imaging, and functional studies reveal how the ESCRT-III protein IST1 recruits the CAPN7 cysteine protease to midbodies, where its proteolytic activity is required for efficient abscission and NoCut checkpoint arrest.
Jayashree Jena, Luis Miguel García-Peña ... Renata O Pereira
Deletion of optic atrophy 1 in brown adipose tissue induces secretion of growth differentiation factor 15 as a batokine to attenuate diet-induced obesity and improve glucose clearance, hepatic steatosis, and thermoregulation in mice by increasing energy expenditure.
