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Alpha-synuclein binding to the synapsin E-domain is essential and sufficient for their cooperation in attenuating synaptic-vesicle trafficking and neurotransmission.

Internal neural variability can induce drift of memory ensembles through synaptic plasticity, allowing for encoding of temporal information.

Genetic and biochemical approaches reveal that mammalian cells possess a novel DDI2 and transcription-independent pathway for the rapid recovery of proteasome activity after clinically relevant pulse treatment with proteasome inhibitors.

Optogenetic manipulation and photometry recordings in the lateral hypothalamus show how interactions between dopamine and orexin systems underlie reward expectation revealing dopaminergic modulation of orexinergic activity via D2 receptors.

Of the two divisions proposed long ago to describe the autonomic nervous system, thoraco-lumbar sympathetic and cranio-sacral parasympathetic, the latter finds no support from transcriptionally defined neuron types.

Protein language deep learning models can quickly and accurately translate amino acid sequences into profile hidden Markov models or a structure alphabet, dramatically improving remote homology search sensitivity without compromising space or time efficiency.

For neurons to prevent undesirable synaptic connections in the brain, the combinatorial expression of γ-PCDH is essential.

Epilepsy caused by focal Pten deletion is only prevented when both mTOR complexes are simultaneously inhibited, but not alone, suggesting they play independent roles in the development of epilepsy.

Unveiling the intricate web of interactions between G4 structures and pathogenicity islands in 89 bacterial genomes significantly advances our understanding of bacterial virulence mechanisms.

Adult Drosophila exposed to auxin at the recommended concentrations for the AGES transgene expression system display defects in feeding behavior, have altered metabolic transcripts, and have reduced triacylglyceride levels.