Genome-wide CRISPR screen identified propionyl-CoA subunit B as a key regulator for anti-tumor T-cell activity in pancreatic cancer, which holds promise for advancing immunotherapy strategies in curing pancreatic cancer.
Derived from scRNA-seq, SLC26A3 is a potential therapeutic target to improve the efficacy of immunotherapy, as well as a potential diagnostic indicator to reduce post-surgical upstaging, for cervical adenocarcinoma.
Zuzana Outla, Gizem Oyman-Eyrilmez ... Martin Gregor
Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy resistance.
Alison G Barber, Cynthia M Quintero ... Tannishtha Reya
The stem cell signal Msi2 plays a dual role in lung cancer, acting as a signal that is not only essential for initiation, but also for propagation of the tumor.
Rui Vasco Simoes, Rafael Neto Henriques ... Noam Shemesh
Deuterium metabolic imaging quantitatively maps glycolytic and mitochondrial oxidation fluxes in mouse glioblastoma and their association with tumor histopathologic features.
