Browse our latest Epidemiology and Global Health articles

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    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway

    Robert Krause, Jumari Snyman ... Alasdair Leslie
    A skewed B cell response in people living with HIV proceeds via an extrafollicular path and could result in reduced affinity B cell memory and antibody responses.
    1. Epidemiology and Global Health

    The role of adolescent lifestyle habits in biological aging: A prospective twin study

    Anna Kankaanpää, Asko Tolvanen ... Elina Sillanpää
    Unhealthy lifestyle habits in adolescence associate with accelerated biological aging in young adulthood, but shared genetic factors underlying both lifestyle and biological aging may largely explain the observed associations.
    1. Epidemiology and Global Health
    2. Medicine

    Lack of ownership of mobile phones could hinder the rollout of mHealth interventions in Africa

    Justin T Okano, Joan Ponce ... Sally Blower
    Due to current levels of mobile phone ownership in Africa, it may only be possible to scale up mHealth interventions in a few countries, but not in the vast majority of the 33 countries that encompass ~60% of Africa's population.
    1. Ecology
    2. Epidemiology and Global Health

    Point of View: The biospheric emergency calls for scientists to change tactics

    Fernando Racimo, Elia Valentini ... Julia B Halder
    The ever-worsening climate and ecological crises calls for life scientists to engage in advocacy and activism to galvanise governments and the public into action.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study

    Oliver Stirrup, James Blackstone ... Judith Breuer
    Sequencing of viral genomes could be useful for infection prevention and control within hospitals, but did not lead to a reduction in the rate of hospital-acquired SARS-CoV-2 infections over winter 2020/2021 in a large multicentre UK study.
    1. Epidemiology and Global Health

    How should COVID-19 vaccines be distributed between the Global North and South: a discrete choice experiment in six European countries

    Janina I Steinert, Henrike Sternberg ... Tim Büthe
    In a large discrete choice experiment, respondents from six European countries reveal preferences for global vaccine solidarity, where female, younger, more educated respondents are most likely to prioritise candidates from the Global South in their allocation choices for COVID-19 vaccines.
    1. Epidemiology and Global Health
    2. Medicine

    The ellipse of insignificance, a refined fragility index for ascertaining robustness of results in dichotomous outcome trials

    David Robert Grimes
    An ellipse of insignificant analysis is a robust method for ascertaining the strength of even large dichotomous outcome trials in biomedical science, and is a novel means to detect potentially dubious results and research fraud.
    1. Epidemiology and Global Health

    Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries

    Xinxuan Li, Yajing Zhou ... Xue Li
    Genetically predicted high insulin-like growth factor levels may decrease the risk of COVID-19 susceptibility and hospitalization.
    1. Epidemiology and Global Health

    Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil

    Max T Eyre, Fábio N Souza ... Federico Costa
    While flooding events may drive spillover transmission of Leptospira spp. through dispersal of the bacteria at low elevations, at higher elevations environmental risk is more localised and directly driven by the distribution of local rat reservoir populations.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers

    Si Fang, Michael V Holmes ... Tom G Richardson
    A comprehensive resource to systematically evaluate the genetically predicted associations between 125 polygenic risk scores and 249 metabolic traits.