Browse our latest Immunology and Inflammation articles

Oligodendroglia express major histocompatibility complex (MHC) pathways in response to inflammation and MHC reporter mice allow for the investigation of MHC molecule expressing cells in vivo.

High cerebrospinal fluid tryptophan levels consistently predict increased mortality in HIV-infected and -uninfected patients in Vietnam and Indonesia.

Selective involvement of Arp2/3 complex subunit isoforms ARPC5 or ARPC5L governs the distinct actin polymerization events in the nucleus or cytoplasm of CD4 T cells that are triggerd by T cell activation or DNA replication stress.

The small macrophage-secreted protein RELMα is a sex-specific protein that protects against diet-induced obesity through regulating the macrophage–eosinophil innate immune axis in the adipose tissue.

Human macrophages infected with Mycobacterium tuberculosis present peptides derived from substrates of type VII secretion systems on MHC class I via a pathway dependent on the ESX-1 secretion system and independent of antigen processing by the proteasome and cathepsins.

Persistence of severe acute respiratory syndrome coronavirus 2 and reactivation of unrelated latent viruses may play a role in the development and pathogenesis of long COVID, and future research should focus on identifying the mechanisms behind these interactions.

A bioinformatics approach shows how to reduce noise in single-cell TCR-pMHC specificity data while retaining sensitivity toward cross-binding events to facilitate investigation of the rules governing TCR-pMHC binding.

Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.

A commonly used immunoglobulin loci-transgenic mouse, the Kymouse, has B cells that go through complete development and have receptor repertoires that show key differences in encoding gene frequencies but structural similarity in their most variable regions.

Human antibodies that neutralize New World hantaviruses are promising for prevention or treatment of these high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person contact.