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Small molecule inhibitors of gut microbial choline trimethylamine lyase activity protect against obesity.

Hunger-sensitive AgRP neurons must sense changes in calorie availability to transmit metabolic information into dopamine release in the NAc and dorsal striatum, albeit over different time frames, to increase motivated food reward seeking.

Patient outcomes, and the time spent by patients during hospital admission, showed considerable variation over the first year of the COVID-19 pandemic.

A small molecule compound Dwn1, identified through high-throughput screening using Npas2 as the molecular target, enhances wound healing in a murine incisional wound model.

A machine learning model could accurately estimate daily salt consumption in the general population and can be applied to countries lacking urine sample to compute the mean salt consumption at the population level.

Personalized virtual-heart technology for arrhythmia risk assessment could transform the management of hypertrophic cardiomyopathy patients, eliminating many unnecessary primary-prevention defibrillator deployments while ensuring patients at high risk for arrhythmia are adequately protected.

Patients with different rs1990760 variants have a differential inflammatory response to severe SARS-CoV-2 infections, so that those with a TT genotype have an attenuated systemic inflammation and may not benefit from steroid therapy.

A series of functional assays in mouse models and primary brown adipocytes confirm that the ACE2 pathway regulates glucose and lipid homeostasis, and maintains thermogenesis and systemic energy metabolism by both the Akt and PKA signaling.

Optimising the use of transcriptomics enables screening of thousands of compounds and illustrates an approach that yields quantitative pharmacology at the single-gene and pathway level.

MIR20B has a deteriorating effect in NAFLD by suppressing PPARA, and may serve as a therapeutic target for combination therapy with fenofibrate for NAFLD.